Literature DB >> 11764993

Bioactivation of toxicants by cytochrome p450-mediated dehydrogenation mechanisms.

G S Yost1.   

Abstract

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Year:  2001        PMID： 11764993     DOI： 10.1007/978-1-4615-0667-6_6

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


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  4 in total

1.  Improved cytochrome P450 3A4 molecular models accurately predict the Phe215 requirement for raloxifene dehydrogenation selectivity.

Authors:  Chad D Moore; Kiumars Shahrokh; Stephen F Sontum; Thomas E Cheatham; Garold S Yost
Journal:  Biochemistry       Date:  2010-10-19       Impact factor: 3.162

2.  Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.

Authors:  Xin Zhou; Jaime D'Agostino; Lei Li; Chad D Moore; Garold S Yost; Xinxin Ding
Journal:  Drug Metab Dispos       Date:  2012-01-06       Impact factor: 3.922

3.  Conformational dynamics of CYP3A4 demonstrate the important role of Arg212 coupled with the opening of ingress, egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen.

Authors:  Kiumars Shahrokh; Thomas E Cheatham; Garold S Yost
Journal:  Biochim Biophys Acta       Date:  2012-06-04

4.  The pneumotoxin 3-methylindole is a substrate and a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract.

Authors:  Jaime D'Agostino; Xiaoliang Zhuo; Mohammad Shadid; Daniel G Morgan; Xiuling Zhang; W Griffith Humphreys; Yue-Zhong Shu; Garold S Yost; Xinxin Ding
Journal:  Drug Metab Dispos       Date:  2009-07-16       Impact factor: 3.922
  4 in total

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