Literature DB >> 1176438

Correlation of the effects of citric acid cycle metabolites on succinate oxidation by rat liver mitochondria and submitochondrial particles.

M Hillar, V Lott, B Lennox.   

Abstract

1. Succinate dehydrogenase is inhibited by citrate and beta-hydroxy-butyrate in a complex manner, both in mitochondria and submitochondrial particles. Kinetics of inhibition in the particles points to a competitive component in the mechanism involved. 2. Pyruvate, alpha-ketoglutarate, malate, and glutamate stimulate oxidation of succinate by mitochondria. 3. Stimulation by alpha-ketoglutarate and glutamate is not influenced by the presence of rotenone. 4. Stimulation by pyruvate is higher in the absence of rotenone and increases significantly in the presence of K+ and valinomycin. Pyruvate supplies in mitochondria reducing equivalents for malate dehydrogenase operating in the reverse direction-reduction of oxaloacetate to malate. 5. Stimulation by malate is higher in the presence of rotenone.

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Year:  1975        PMID： 1176438     DOI： 10.1007/bf01558459

Source DB:  PubMed          Journal:  J Bioenerg        ISSN： 0449-5705


  34 in total

1.  Properties of the two forms of malic dehydrogenase from beef heart.

Authors:  F C GRIMM; D G DOHERTY
Journal:  J Biol Chem       Date:  1961-07       Impact factor: 5.157

2.  The relation of alpha-glycerophosphate dehydrogenase to the respiratory chain in brain mitochondria.

Authors:  R L RINGLER; T P SINGER
Journal:  Arch Biochem Biophys       Date:  1958-09       Impact factor: 4.013

3.  Studies on succinic dehydrogenase. IV. Activation of the beef heart enzyme.

Authors:  E B KEARNEY
Journal:  J Biol Chem       Date:  1957-11       Impact factor: 5.157

4.  The effect of fluoride on the succinic oxidase system.

Authors:  E C SLATER; W D BORNER
Journal:  Biochem J       Date:  1952-10       Impact factor: 3.857

5.  Regulatory properties of succinate dehydrogenase: activation by succinyl CoA, pH, and anions.

Authors:  E B Kearney; M Mayr; T P Singer
Journal:  Biochem Biophys Res Commun       Date:  1972-01-31       Impact factor: 3.575

6.  Oxaloacetate inhibition of succinate oxidation in tightly coupled liver mitochondria with ferricyanide as an electron acceptor.

Authors:  G L Dohm; E B Tapscott
Journal:  Biochem Biophys Res Commun       Date:  1973-05-01       Impact factor: 3.575

7.  On the transport of inorganic phosphate and malate in rat-liver mitochondria.

Authors:  S Papa; N E Lofrumento; M Loglisci; E Quagliariello
Journal:  Biochim Biophys Acta       Date:  1969-10-21

8.  The uptake of C4-dicarboxylic acids by Escherichia coli.

Authors:  W W Kay; H L Kornberg
Journal:  Eur J Biochem       Date:  1971-01

9.  Studies on succinate dehydrogenase. II. On the nature of the reaction of competitive inhibitors and substrates with succinate dehydrogenase.

Authors:  D V Dervartanian; C Veeger
Journal:  Biochim Biophys Acta       Date:  1965-09-20

10.  Factors affecting the translocation of oxaloacetate and L-malate into rat liver mitochondria.

Authors:  J M Haslam; D E Griffiths
Journal:  Biochem J       Date:  1968-10       Impact factor: 3.857
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  9 in total

1.  The control of mitochondrial succinate-dependent H2O2 production.

Authors:  Franco Zoccarato; Claudio Miotto; Lucia Cavallini; Adolfo Alexandre
Journal:  J Bioenerg Biomembr       Date:  2011-07-07       Impact factor: 2.945

2.  Cellular citrate levels establish a regulatory link between energy metabolism and the hepatic iron hormone hepcidin.

Authors:  Ana Rita da Silva; Joana Neves; Katarzyna Mleczko-Sanecka; Amol Tandon; Sven W Sauer; Matthias W Hentze; Martina U Muckenthaler
Journal:  J Mol Med (Berl)       Date:  2017-06-05       Impact factor: 4.599

3.  Temperature sensitivity of cardiac mitochondria in intertidal and subtidal triplefin fishes.

Authors:  Zoë Hilton; Kendall D Clements; Anthony J R Hickey
Journal:  J Comp Physiol B       Date:  2010-05-12       Impact factor: 2.200

Review 4.  Multiple roles played by the mitochondrial citrate carrier in cellular metabolism and physiology.

Authors:  Vincenzo Zara; Graziana Assalve; Alessandra Ferramosca
Journal:  Cell Mol Life Sci       Date:  2022-07-17       Impact factor: 9.207

5.  Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo.

Authors:  Marie Pereira; Tai-Di Chen; Norzawani Buang; Antoni Olona; Jeong-Hun Ko; Maria Prendecki; Ana S H Costa; Efterpi Nikitopoulou; Laura Tronci; Charles D Pusey; H Terence Cook; Stephen P McAdoo; Christian Frezza; Jacques Behmoaras
Journal:  Cell Rep       Date:  2019-07-09       Impact factor: 9.423

Review 6.  Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of Immune Responses.

Authors:  Inseok Choi; Hyewon Son; Jea-Hyun Baek
Journal:  Life (Basel)       Date:  2021-01-19

7.  Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway.

Authors:  Jian-Guo Ren; Pankaj Seth; Huihui Ye; Kun Guo; Jun-Ichi Hanai; Zaheed Husain; Vikas P Sukhatme
Journal:  Sci Rep       Date:  2017-07-03       Impact factor: 4.379

8.  Combination of Mitochondrial and Plasma Membrane Citrate Transporter Inhibitors Inhibits De Novo Lipogenesis Pathway and Triggers Apoptosis in Hepatocellular Carcinoma Cells.

Authors:  Wan-Angkan Poolsri; Phornpun Phokrai; Somrudee Suwankulanan; Narinthorn Phakdeeto; Pattamaphorn Phunsomboon; Dumrongsak Pekthong; Lysiane Richert; Sutatip Pongcharoen; Piyarat Srisawang
Journal:  Biomed Res Int       Date:  2018-01-09       Impact factor: 3.411

Review 9.  A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation.

Authors:  Niamh C Williams; Luke A J O'Neill
Journal:  Front Immunol       Date:  2018-02-05       Impact factor: 7.561
  9 in total

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