Literature DB >> 1176210

Mutation induction in Chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2-chloroacetaldehyde.

E Huberman, H Bartsch, L Sachs.   

Abstract

Chloroethylene oxide and 2-chloroacetaldehyde, two possibly carcinogenic metabolities of vinyl chloride in mammals, caused a dose-dependent induction of 8-azaguanine- and ouabain-resistant mutants in Chinese hamster V79 cells in vitro. Up to one-hundred-fold higher concentrations of 2-chloroethanol or monochloroacetic acid, a urinary vinyl chloride metabolite in rats and man, were inactive.

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Year:  1975        PMID： 1176210     DOI： 10.1002/ijc.2910160414

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  4 in total

1.  Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases.

Authors:  H Bartsch; C Malaveille; A Barbin; G Planche
Journal:  Arch Toxicol       Date:  1979-02-23       Impact factor: 5.153

2.  Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced DNA adduct N(2),3-ethenoguanine in tissues of adult and weanling rats following exposure to [(13)C(2)]-VC.

Authors:  Esra Mutlu; Leonard B Collins; Matthew D Stout; Patricia B Upton; Laura R Daye; Darrell Winsett; Gary Hatch; Paul Evansky; James A Swenberg
Journal:  Chem Res Toxicol       Date:  2010-09-20       Impact factor: 3.739

3.  Malignant tumors after chronic exposure to vinyl chloride.

Authors:  K H Emmerich; K Norpoth
Journal:  J Cancer Res Clin Oncol       Date:  1981       Impact factor: 4.553

4.  Studies on the miscoding properties of 1,N6-ethenoadenine and 3,N4-ethenocytosine, DNA reaction products of vinyl chloride metabolites, during in vitro DNA synthesis.

Authors:  A Barbin; H Bartsch; P Leconte; M Radman
Journal:  Nucleic Acids Res       Date:  1981-01-24       Impact factor: 16.971
  4 in total

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