Literature DB >> 1176135

Cytogenetic effects of cyclophosphamide on mouse spermatogonia.

R Rathenberg.   

Abstract

NMRI mice were treated with single doses of cyclophosphamide (Cytoxan) and spermatogonia were analysed for chromosome aberrations at various time intervals after treatment. The maxima of aberrations were found 24 hrs p.i. Chromatid type aberrations were observed exclusively. About half of the aberrations consisted of chromatid interchanges, 92% of which exchanging short arm fragments close to the centromeric region. The lack of meiotic multivalents in diakinesis-metaphase I after treatment of spermatogonia stem cells with cyclophosphamide in the study of Leonard and Linden (1972) is discussed.

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Year:  1975        PMID： 1176135     DOI： 10.1007/bf00430350

Source DB:  PubMed          Journal:  Humangenetik        ISSN： 0018-7348


  10 in total

1.  Observation of dividing spermatocytes for chromosome aberrations induced in mouse spermatogonia by chemical mutagens.

Authors:  A Leonard; G Linden
Journal:  Mutat Res       Date:  1972-11       Impact factor: 2.433

2.  Comparative cytogenetic study after treatment of mouse spermatogonia with mitomycin C.

Authors:  I D Adler
Journal:  Mutat Res       Date:  1974-06       Impact factor: 2.433

3.  Action of mitomycin C on mouse spermatogonia.

Authors:  A Manyak; E Schleiermacher
Journal:  Mutat Res       Date:  1973-07       Impact factor: 2.433

4.  [On the effects of trenimon and endoxan on meiosis in male mice. I. Method of preparation and analysis of meiotic divisions].

Authors:  E Schleiermacher
Journal:  Humangenetik       Date:  1966

5.  Comparative cytogenetic studies of the influence of phenylbutazone and cyclophosphamide on spermatogenesis in the mouse.

Authors:  R Rathenberg; D Müller
Journal:  Agents Actions       Date:  1972-06

6.  The effects of cytoxan on the chromosomes of mouse bone marrow.

Authors:  P K Datta; E Schleiermacher
Journal:  Mutat Res       Date:  1969 Nov-Dec       Impact factor: 2.433

7.  [Chromosome aberrations in human peripheral lymphocytes following Endoxan massive-dose therapy of gynecological tumors].

Authors:  E Schmid; M Bauchinger
Journal:  Dtsch Med Wochenschr       Date:  1968-06       Impact factor: 0.628

8.  Chromosome studies on bone marrow from Chinese hamsters treated with benzodiazepine tranquillizers and cyclophosphamide.

Authors:  W Schmid; G R Staiger
Journal:  Mutat Res       Date:  1969 Jan-Feb       Impact factor: 2.433

9.  [On the effects of trenimon and endoxan on meiosis in male mice. II. Cytogenetic findings after treatment with trenimon and endoxan].

Authors:  E Schleiermacher
Journal:  Humangenetik       Date:  1966

10.  [The mutagenic effect of endoxan on the mouse].

Authors:  D Brittinger
Journal:  Humangenetik       Date:  1966
  10 in total
  3 in total

1.  The effect of cyclophosphamide on the centromere separation sequence in Chinese hamster spermatogonia.

Authors:  J R Singh; H G Miltenburger
Journal:  Hum Genet       Date:  1977-12-23       Impact factor: 4.132

2.  The effect of isoniazid (INH) on Chinese hamster and mouse spermatogonia.

Authors:  H G Miltenburger; H Träger; I D Adler; A Schmaltz; R Rathenberg; H Schwegler; I H Pawlowitzki; C Nautsch; D Müller
Journal:  Hum Genet       Date:  1978-05-16       Impact factor: 4.132

3.  In vivo BrdU-33258 Hoechst analysis of DNA replication kinetics and sister chromatid exchange formation in mouse somatic and meiotic cells.

Authors:  J W Allen; S A Latt
Journal:  Chromosoma       Date:  1976-11-29       Impact factor: 4.316
  3 in total

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