Retroviral insertion into herpesviruses: discovery and implications.

Retroviruses and herpesviruses are important human pathogens. Co-infections of these viruses in hosts often exist and co-infection of the same cell type is also common. In this report, we will review the evidence that supports the contention that retrovirus insertion into herpesvirus can occur in vitro and in vivo. We will also discuss retrovirus insertion into other large DNA viruses.