PURPOSE: Microwave thermal keratoplasty applies microwave energy to elevate the temperature of the paracentral stroma of the cornea to its thermal shrinkage temperature of about 60 degrees C. A suitable pattern of shrinkage in the paracentral cornea can flatten the central cornea. A surface cooling system preserves the epithelium during the procedure. METHODS: Fourteen enucleated porcine eyes were treated with a prototype microwave thermal keratoplasty applicator that heated in a ring pattern with inner diameter of 3.2 mm and width of 0.7 mm. The change in corneal power was quantified by a videokeratoscope. Slit-lamp microscope examinations and histological assessments were made. RESULTS: The 3-mm simulated keratometry reading showed an average of 6.60+/-6.00 D (standard deviation) of flattening. The region of opacity associated with shrinkage extended to 62% (+/-26%) of the corneal thickness. The epithelium was intact in all eyes. CONCLUSIONS: Microwave thermal keratoplasty applied in the paracentral cornea may flatten the central cornea.
PURPOSE: Microwave thermal keratoplasty applies microwave energy to elevate the temperature of the paracentral stroma of the cornea to its thermal shrinkage temperature of about 60 degrees C. A suitable pattern of shrinkage in the paracentral cornea can flatten the central cornea. A surface cooling system preserves the epithelium during the procedure. METHODS: Fourteen enucleated porcine eyes were treated with a prototype microwave thermal keratoplasty applicator that heated in a ring pattern with inner diameter of 3.2 mm and width of 0.7 mm. The change in corneal power was quantified by a videokeratoscope. Slit-lamp microscope examinations and histological assessments were made. RESULTS: The 3-mm simulated keratometry reading showed an average of 6.60+/-6.00 D (standard deviation) of flattening. The region of opacity associated with shrinkage extended to 62% (+/-26%) of the corneal thickness. The epithelium was intact in all eyes. CONCLUSIONS: Microwave thermal keratoplasty applied in the paracentral cornea may flatten the central cornea.
Authors: Alicia A Petryk; Robert V Stigliano; Andrew J Giustini; Rachel E Gottesman; B Stuart Trembly; Peter A Kaufman; P Jack Hoopes Journal: Proc SPIE Int Soc Opt Eng Date: 2011-02-22
Authors: Alicia A Petryk; Andrew J Giustini; Rachel E Gottesman; B Stuart Trembly; P Jack Hoopes Journal: Int J Hyperthermia Date: 2013-12 Impact factor: 3.914