Literature DB >> 11757815

The gastrointestinal pharmacology of cannabinoids.

A A Izzo1, N Mascolo, F Capasso.   

Abstract

The digestive tract contains endogenous cannabinoids (anandamide and 2-arachidonylglycerol) and cannabinoid CB1 receptors can be found on myenteric and submucosal nerves. Activation of CB1 receptors inhibits gastrointestinal motility, intestinal secretion and gastric acid secretion. The enteric location of CB1 receptors could provide new strategies for the management of gut disorders.

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Year:  2001        PMID： 11757815     DOI： 10.1016/s1471-4892(01)00102-3

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  18 in total

1.  ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells.

Authors:  Edward C Y Wang; Jey-Myung Lee; Wily G Ruiz; Elena M Balestreire; Maximilian von Bodungen; Stacey Barrick; Debra A Cockayne; Lori A Birder; Gerard Apodaca
Journal:  J Clin Invest       Date:  2005-08-18       Impact factor: 14.808

2.  Investigation on the relationship between cannabinoid CB1 and opioid receptors in gastrointestinal motility in mice.

Authors:  Mauro A M Carai; Giancarlo Colombo; Gian Luigi Gessa; Ratnakumar Yalamanchili; Balapal S Basavarajappa; Balapal S Basavarajppa; Basalingappa L Hungund
Journal:  Br J Pharmacol       Date:  2006-07-17       Impact factor: 8.739

3.  Cannabinoid CB(1) receptor and gastric acid secretion.

Authors:  Francesca Borrelli
Journal:  Dig Dis Sci       Date:  2007-11       Impact factor: 3.199

4.  Modulation of gut-specific mechanisms by chronic δ(9)-tetrahydrocannabinol administration in male rhesus macaques infected with simian immunodeficiency virus: a systems biology analysis.

Authors:  Patricia E Molina; Angela M Amedee; Nicole J LeCapitaine; Jovanny Zabaleta; Mahesh Mohan; Peter J Winsauer; Curtis Vande Stouwe; Robin R McGoey; Matthew W Auten; Lynn LaMotte; Lawrance C Chandra; Leslie L Birke
Journal:  AIDS Res Hum Retroviruses       Date:  2014-02-07       Impact factor: 2.205

5.  The endogenous cannabinoid system protects against colonic inflammation.

Authors:  Federico Massa; Giovanni Marsicano; Heike Hermann; Astrid Cannich; Krisztina Monory; Benjamin F Cravatt; Gian-Luca Ferri; Andrei Sibaev; Martin Storr; Beat Lutz
Journal:  J Clin Invest       Date:  2004-04       Impact factor: 14.808

6.  Cannabinoid CB1 receptors are expressed by parietal cells of the human gastric mucosa.

Authors:  María Ruth Pazos; Rosa María Tolón; Cristina Benito; Conrado Fernández Rodríguez; Juan José Gorgojo; Manuel Nevado; Mariano Alvarez; Francisco Arias; Francisca Almodóvar; María Teresa Pérez Fernández; José Luis Lledó; Sara González; José Javier Fernández-Ruiz; Julián Romero
Journal:  J Histochem Cytochem       Date:  2008-02-18       Impact factor: 2.479

7.  Effects of cannabinoid receptor agonists on rat gastric acid secretion: discrepancy between in vitro and in vivo data.

Authors:  Gabriella Coruzzi; Maristella Adami; Elena Guaita; Alessandro Menozzi; Simone Bertini; Elena Giovannini; Giulio Soldani
Journal:  Dig Dis Sci       Date:  2006-02       Impact factor: 3.199

Review 8.  RhoA/Rho-kinase: pathophysiologic and therapeutic implications in gastrointestinal smooth muscle tone and relaxation.

Authors:  Satish Rattan; Benjamin R Phillips; Pinckney J Maxwell
Journal:  Gastroenterology       Date:  2009-11-23       Impact factor: 22.682

9.  Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis.

Authors:  Martin A Storr; Catherine M Keenan; Hong Zhang; Kamala D Patel; Alexandros Makriyannis; Keith A Sharkey
Journal:  Inflamm Bowel Dis       Date:  2009-11       Impact factor: 5.325

10.  Ulcerative colitis induces changes on the expression of the endocannabinoid system in the human colonic tissue.

Authors:  Lucia Marquéz; Juan Suárez; Mar Iglesias; Francisco Javier Bermudez-Silva; Fernando Rodríguez de Fonseca; Montserrat Andreu
Journal:  PLoS One       Date:  2009-09-04       Impact factor: 3.240
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