| Literature DB >> 11757171 |
P W Roche1, K D Neupane, S S Failbus, A Kamath, W J Britton.
Abstract
A DNA vaccine composed of the gene for the common mycobacterial secreted protein antigen 85B was demonstrated to protect the mouse foot pad against infection with Mycobacterium leprae. The protective effect was demonstrated by a 61%-88% reduction in the bacterial number, a protective effect less than that of BCG. The same DNA vaccine has been shown to protect mice against M. tuberculosis infection, and the importance of testing other candidate tuberculosis vaccines for their potential to protect against leprosy is discussed.Entities:
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Year: 2001 PMID： 11757171
Source DB: PubMed Journal: Int J Lepr Other Mycobact Dis ISSN： 0148-916X