Literature DB >> 1175622

Isolation and identification of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid from the urine of a patient with sialuria.

J P Kamerling, J F Vliegenthart.   

Abstract

N-Acetylneuraminic acid preparations from the urine of a patient with sialuria contain 1--2% of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. This new human sialic acid was isolated by ion-exchange and partition chromatography. The structure has been elucidated by mass spectrometry and confirmed by comparison with the synthetic compound. The properties of this unsaturated sialic acid in the orcinol/Fe3+/HCl and the periodic acid/thiobarbituric acid tests as well as in thin-layer and gas-liquid chromatography are described. It does not react with acylneuraminate pyruvatelyase. The origin of this new human sialic acid is discussed.

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Year:  1975        PMID： 1175622     DOI： 10.1111/j.1432-1033.1975.tb02228.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  7 in total

Review 1.  Neuropathology of Salla disease.

Authors:  H Autio-Harmainen; A Oldfors; P Sourander; M Renlund; K Dammert; S Similä
Journal:  Acta Neuropathol       Date:  1988       Impact factor: 17.088

2.  Effects of GM1 and 2-deoxy-2,3-dehydro-N-acetylneuraminic acid (NeuAc2en) on neuroblastoma (Neuro 2a) and human glioma cells (U1242 MG).

Authors:  H el Sayed; J D Agudelo; D K Pearl; A J Yates
Journal:  J Neurooncol       Date:  1991-12       Impact factor: 4.130

3.  Biochemical characterization of patients and prenatal diagnosis of sialic acid storage disease for three families.

Authors:  P R Clements; J A Taylor; J J Hopwood
Journal:  J Inherit Metab Dis       Date:  1988       Impact factor: 4.982

Review 4.  Achievements and challenges of sialic acid research.

Authors:  R Schauer
Journal:  Glycoconj J       Date:  2000 Jul-Sep       Impact factor: 2.916

Review 5.  Exploration of the Sialic Acid World.

Authors:  Roland Schauer; Johannis P Kamerling
Journal:  Adv Carbohydr Chem Biochem       Date:  2018-11-28       Impact factor: 12.200

6.  Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.

Authors:  Weiwu Ren; Robert Pengelly; Marco Farren-Dai; Saeideh Shamsi Kazem Abadi; Verena Oehler; Oluwafemi Akintola; Jason Draper; Michael Meanwell; Saswati Chakladar; Katarzyna Świderek; Vicent Moliner; Robert Britton; Tracey M Gloster; Andrew J Bennet
Journal:  Nat Commun       Date:  2018-08-13       Impact factor: 14.919

Review 7.  The structure of gangliosides hides a code for determining neuronal functions.

Authors:  Giulia Lunghi; Maria Fazzari; Erika Di Biase; Laura Mauri; Elena Chiricozzi; Sandro Sonnino
Journal:  FEBS Open Bio       Date:  2021-06-15       Impact factor: 2.693
  7 in total

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