BACKGROUND: Zinc deficiency limits the bioavailability of vitamin A. Because zinc and vitamin A deficiency often coexist in malnourished children, simultaneous zinc and vitamin A supplementation may improve the vitamin A deficiency in these children. OBJECTIVE: A randomized, double-blind, placebo-controlled intervention trial was conducted to evaluate whether combining zinc and vitamin A supplementation would improve the biochemical indexes of vitamin A nutriture. DESIGN:Children aged 12-35 mo were randomly assigned to 1 of 4 intervention groups: 20 mg Zn/d for 14 d (Z group), 60000 retinol equivalents (200000 IU) vitamin A on day 14 (A group), zinc plus vitamin A (ZA group), or placebo syrup and placebo capsule (placebo group). Venous blood was drawn at enrollment and on day 21. RESULTS:Mean serum retinol concentrations were not significantly different between the A and ZA groups. Among vitamin A-deficient children, the proportion of children who remained vitamin A deficient (serum retinol <0.7 micromol/L) after supplementation was 40.6% in the Z group, 37.5% in the A group, and 47.0% in the placebo group; only 13.3% in the ZA group remained vitamin A deficient (P < 0.05 compared with the placebo group). The proportion of children whose retinol binding protein concentrations remained low was significantly lower in the ZA group than in the other groups (P < 0.05). CONCLUSION:Combined zinc and vitamin A supplementation improves vitamin A nutriture in vitamin A-deficient children.
RCT Entities:
BACKGROUND: Zinc deficiency limits the bioavailability of vitamin A. Because zinc and vitamin A deficiency often coexist in malnourished children, simultaneous zinc and vitamin A supplementation may improve the vitamin A deficiency in these children. OBJECTIVE: A randomized, double-blind, placebo-controlled intervention trial was conducted to evaluate whether combining zinc and vitamin A supplementation would improve the biochemical indexes of vitamin A nutriture. DESIGN:Children aged 12-35 mo were randomly assigned to 1 of 4 intervention groups: 20 mg Zn/d for 14 d (Z group), 60000 retinol equivalents (200000 IU) vitamin A on day 14 (A group), zinc plus vitamin A (ZA group), or placebo syrup and placebo capsule (placebo group). Venous blood was drawn at enrollment and on day 21. RESULTS: Mean serum retinol concentrations were not significantly different between the A and ZA groups. Among vitamin A-deficient children, the proportion of children who remained vitamin A deficient (serum retinol <0.7 micromol/L) after supplementation was 40.6% in the Z group, 37.5% in the A group, and 47.0% in the placebo group; only 13.3% in the ZA group remained vitamin A deficient (P < 0.05 compared with the placebo group). The proportion of children whose retinol binding protein concentrations remained low was significantly lower in the ZA group than in the other groups (P < 0.05). CONCLUSION: Combined zinc and vitamin A supplementation improves vitamin A nutriture in vitamin A-deficient children.
Authors: E Venneria; F Intorre; M S Foddai; E Azzini; L Palomba; A Raguzzini; A Polito; D Ciarapica; M Zaccaria; E Toti; G Catasta; G Maiani Journal: J Nutr Health Aging Date: 2014-04 Impact factor: 4.075
Authors: Vivienne Woo; Emily M Eshleman; Seika Hashimoto-Hill; Jordan Whitt; Shu-En Wu; Laura Engleman; Taylor Rice; Rebekah Karns; Joseph E Qualls; David B Haslam; Bruce A Vallance; Theresa Alenghat Journal: Cell Host Microbe Date: 2021-10-21 Impact factor: 21.023
Authors: Kelly A Dougherty; Joan I Schall; Deborah A Kawchak; Michael H Green; Kwaku Ohene-Frempong; Babette S Zemel; Virginia A Stallings Journal: Am J Clin Nutr Date: 2012-09-05 Impact factor: 7.045
Authors: Sunil Sazawal; Usha Dhingra; Saikat Deb; Maharaj K Bhan; Venugopal P Menon; Robert E Black Journal: J Health Popul Nutr Date: 2007-03 Impact factor: 2.000