OBJECTIVE: To compare placental pathology between women with and without thrombophilia who had severe preeclampsia, intrauterine growth retardation, severe abruptio placentae, or stillbirth. METHODS: After delivery, 68 women with singleton pregnancies with one of the above complications were evaluated for an inherited thrombophilia: factor V Leiden, methylenetetrahydrofolate reductase and prothrombin gene mutation, and deficiencies of protein S, protein C, and antithrombin III. Thirty-two women were thrombophilic (group A), and 36 women were not (group B). There was no difference in maternal age, parity, and type of pregnancy complication. A single pathologist examined each placenta. RESULTS: The gestational age at delivery, birth weight, and placental weight were significantly lower in group A. Three parameters showed significant differences between the groups: thrombophilic women had a higher number of villous infarcts (P <.01), more multiple infarcts (P <.05), and a higher incidence of placentas with fibrinoid necrosis of decidual vessels (P <.05). CONCLUSION: Placentas of women with severe complications and thrombophilia have an increased rate of vascular lesions.
OBJECTIVE: To compare placental pathology between women with and without thrombophilia who had severe preeclampsia, intrauterine growth retardation, severe abruptio placentae, or stillbirth. METHODS: After delivery, 68 women with singleton pregnancies with one of the above complications were evaluated for an inherited thrombophilia: factor V Leiden, methylenetetrahydrofolate reductase and prothrombin gene mutation, and deficiencies of protein S, protein C, and antithrombin III. Thirty-two women were thrombophilic (group A), and 36 women were not (group B). There was no difference in maternal age, parity, and type of pregnancy complication. A single pathologist examined each placenta. RESULTS: The gestational age at delivery, birth weight, and placental weight were significantly lower in group A. Three parameters showed significant differences between the groups: thrombophilic women had a higher number of villous infarcts (P <.01), more multiple infarcts (P <.05), and a higher incidence of placentas with fibrinoid necrosis of decidual vessels (P <.05). CONCLUSION: Placentas of women with severe complications and thrombophilia have an increased rate of vascular lesions.
Authors: Beverly Barton Rogers; Valerija Momirova; Donna Dizon-Townson; Katharine Wenstrom; Philip Samuels; Baha Sibai; Catherine Spong; Steve N Caritis; Yoram Sorokin; Menachem Miodovnik; Mary J O'Sullivan; Deborah Conway; Ronald J Wapner Journal: Pediatr Dev Pathol Date: 2010-02-01
Authors: Julia Warner Gargano; Claudia B Holzman; Patricia K Senagore; M Lynne Reuss; Dorothy R Pathak; Karen H Friderici; Katherine Jernigan; Rachel Fisher Journal: Am J Obstet Gynecol Date: 2009-09 Impact factor: 8.661
Authors: Virginia S Baker; Godwin E Imade; Norman B Molta; Pallavi Tawde; Sunday D Pam; Michael O Obadofin; Soloman A Sagay; Daniel Z Egah; Daniel Iya; Bangmboye B Afolabi; Murray Baker; Karen Ford; Robert Ford; Kenneth H Roux; Thomas Cs Keller Journal: Malar J Date: 2008-02-29 Impact factor: 2.979