| Literature DB >> 11755336 |
David J Rawson1, Kevin N Dack, Roger P Dickinson, Kim James.
Abstract
Conformational constraint has been used as the key design element in the identification of a series of potent and selective ET(A) antagonists. The most potent antagonist, 32, (ET(A) IC(50)=0.55nM) is 722-fold selective over the ET(B) receptor, as measured by binding experiments.Entities:
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Year: 2002 PMID： 11755336 DOI： 10.1016/s0960-894x(01)00660-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823