Literature DB >> 11754985

The regulation of human corticotrophin-releasing hormone gene expression in the placenta.

B R King1, R Smith, R C Nicholson.   

Abstract

Corticotrophin-releasing hormone (CRH) is a 41 amino acid neuropeptide that is expressed in the hypothalamus and the human placenta. Placental CRH production has been linked to the determination of gestational length in the human. Although encoded by a single copy gene, CRH expression in the placenta is regulated differently to the hypothalamus. Glucocorticoids stimulate CRH promoter activity in the placenta but inhibit it's activity in the hypothalamus, via mechanisms involving different regions of the CRH promoter. We discuss how various stimuli alter CRH promoter activity and why these responses are unique to the placenta.

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Year:  2001        PMID： 11754985     DOI： 10.1016/s0196-9781(01)00486-7

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  15 in total

1.  Low serum secretory immunoglobulin A level and sense of coherence score at an early gestational stage as indicators for subsequent threatened premature birth.

Authors:  Naomi Sekizuka; Akemi Sakai; Keiko Shimada; Noriko Tabuchi; Yukie Kameda; Hiroyuki Nakamura
Journal:  Environ Health Prev Med       Date:  2009-07-07       Impact factor: 3.674

2.  Pregnancy anxiety and prenatal cortisol trajectories.

Authors:  Heidi S Kane; Christine Dunkel Schetter; Laura M Glynn; Calvin J Hobel; Curt A Sandman
Journal:  Biol Psychol       Date:  2014-04-21       Impact factor: 3.251

Review 3.  Maternal programming: Application of a developmental psychopathology perspective.

Authors:  Laura M Glynn; Mariann A Howland; Molly Fox
Journal:  Dev Psychopathol       Date:  2018-08

4.  Minocycline alleviates sevoflurane-induced cognitive impairment in aged rats.

Authors:  Yue Tian; Shanbin Guo; Xiuying Wu; Ling Ma; Xiaochun Zhao
Journal:  Cell Mol Neurobiol       Date:  2015-01-14       Impact factor: 5.046

5.  Cortical Thinning and Neuropsychiatric Outcomes in Children Exposed to Prenatal Adversity: A Role for Placental CRH?

Authors:  Curt A Sandman; Megan M Curran; Elysia Poggi Davis; Laura M Glynn; Kevin Head; Tallie Z Baram
Journal:  Am J Psychiatry       Date:  2018-03-02       Impact factor: 18.112

6.  Timing of fetal exposure to stress hormones: effects on newborn physical and neuromuscular maturation.

Authors:  Lauren M Ellman; Christine Dunkel Schetter; Calvin J Hobel; Aleksandra Chicz-Demet; Laura M Glynn; Curt A Sandman
Journal:  Dev Psychobiol       Date:  2008-04       Impact factor: 3.038

7.  Psychological predictors of gestational outcomes in second trimester pregnant women: associations with daily uplifts.

Authors:  R T Amiel Castro; U Ehlert; S M Dainese; R Zimmerman; P La Marca-Ghaemmaghami
Journal:  Arch Gynecol Obstet       Date:  2020-04       Impact factor: 2.344

Review 8.  Stressed-out, or in (utero)?

Authors:  Sarit Avishai-Eliner; Kristen L Brunson; Curt A Sandman; Tallie Z Baram
Journal:  Trends Neurosci       Date:  2002-10       Impact factor: 13.837

9.  Corticotropin-Releasing Hormone (CRH) Programs the Fetal and Maternal Brain.

Authors:  Curt A Sandman; Laura M Glynn
Journal:  Future Neurol       Date:  2009-05

10.  Early onset pre-eclampsia is associated with altered DNA methylation of cortisol-signalling and steroidogenic genes in the placenta.

Authors:  Kirsten Hogg; John D Blair; Deborah E McFadden; Peter von Dadelszen; Wendy P Robinson
Journal:  PLoS One       Date:  2013-05-07       Impact factor: 3.240
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