Literature DB >> 11754827

Calcium/calmodulin: a synaptic antidepressant?

G Matthews1.   

Abstract

Synaptic depression contributes to short-term changes in synaptic efficacy during sustained activity. Sakaba and Neher (2001) have characterized two kinetically distinct pools of releasable vesicles whose depletion underlies depression at a CNS synapse. Calcium/calmodulin dramatically accelerates replenishment of one of these pools--and hence recovery from depression.

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Year:  2001        PMID： 11754827     DOI： 10.1016/s0896-6273(01)00546-3

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  2 in total

1.  Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca2+/calmodulin-dependent pathway.

Authors:  Jianyuan Sun; Peter Bronk; Xinran Liu; Weiping Han; Thomas C Südhof
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-15       Impact factor: 11.205

2.  Decreased expression of synapse-related genes and loss of synapses in major depressive disorder.

Authors:  Hyo Jung Kang; Bhavya Voleti; Tibor Hajszan; Grazyna Rajkowska; Craig A Stockmeier; Pawel Licznerski; Ashley Lepack; Mahesh S Majik; Lak Shin Jeong; Mounira Banasr; Hyeon Son; Ronald S Duman
Journal:  Nat Med       Date:  2012-09       Impact factor: 53.440
  2 in total

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