Literature DB >> 11753434

Comparative studies of the biological activities of lysosomotropic aminoesters and quaternary ammonium salts on the yeast Saccharomyces cerevisiae.

E Obłak1, T M Lachowicz, J Luczyński, S Witek.   

Abstract

The biological activity of lysosomotropic n-alkyl N,N-dimethylglycinates (DMG-n) was compared with that of a quaternary ammonium salt IM (methochloride of DMG-12). The activity of the glycinates appeared to be carbon chain length dependent and was similar at pH 6 and pH 8. Nutritional auxotrophy and respiratory deficiencies have no influence on DMG-n sensitivity. Both IM and DMG-n inhibit plasma membrane H+-ATPase activity while mitochondrial ATPase is relatively non-sensitive to glycinates. No cross-resistance to IM and DMG-n was observed.

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Year:  2001        PMID： 11753434

Source DB:  PubMed          Journal:  Cell Mol Biol Lett        ISSN： 1425-8153            Impact factor:   5.787


  6 in total

1.  Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.

Authors:  Aiping Bai; Zdzislaw M Szulc; Jacek Bielawski; Jason S Pierce; Barbara Rembiesa; Silva Terzieva; Cungui Mao; Ruijuan Xu; Bill Wu; Christopher J Clarke; Benjamin Newcomb; Xiang Liu; James Norris; Yusuf A Hannun; Alicja Bielawska
Journal:  Bioorg Med Chem       Date:  2014-10-22       Impact factor: 3.641

2.  Hemolysis of erythrocytes and erythrocyte membrane fluidity changes by new lysosomotropic compounds.

Authors:  Halina Kleszczyńska; Dorota Bonarska; Jacek Luczyński; Stanisław Witek; Janusz Sarapuk
Journal:  J Fluoresc       Date:  2005-03       Impact factor: 2.217

3.  Quaternary ammonium salt N-(dodecyloxycarboxymethyl)-N,N,N-trimethyl ammonium chloride induced alterations in Saccharomyces cerevisiae physiology.

Authors:  Ewa Oblak; Agata Piecuch; Ewa Maciaszczyk-Dziubinska; Donata Wawrzycka
Journal:  J Biosci       Date:  2016-12       Impact factor: 1.826

4.  The physiological and morphological phenotype of a yeast mutant resistant to the quaternary ammonium salt N-(dodecyloxycarboxymethyl)-N,N,N-trimethyl ammonium chloride.

Authors:  Ewa Obłak; Andrzej Gamian; Ryszard Adamski; Stanisław Ułaszewski
Journal:  Cell Mol Biol Lett       Date:  2010-01-29       Impact factor: 5.787

5.  Structurally Related Liposomes Containing N-Oxide Surfactants: Physicochemical Properties and Evaluation of Antimicrobial Activity in Combination with Therapeutically Available Antibiotics.

Authors:  Sara Battista; Pierangelo Bellio; Lorenza Fagnani; Elena Allegritti; Lisaurora Nazzicone; Luciano Galantini; Giuseppe Celenza; Luisa Giansanti
Journal:  Mol Pharm       Date:  2022-02-16       Impact factor: 4.939

Review 6.  Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance.

Authors:  Yang Jiao; Li-Na Niu; Sai Ma; Jing Li; Franklin R Tay; Ji-Hua Chen
Journal:  Prog Polym Sci       Date:  2017-03-12       Impact factor: 29.190
  6 in total

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