| Literature DB >> 11753416 |
P J Coffey1, S Girman, S M Wang, L Hetherington, D J Keegan, P Adamson, J Greenwood, R D Lund.
Abstract
Cell transplantation is one way of limiting the progress of retinal degeneration in animal models of blinding diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD). Here we transplanted a human retinal pigment epithelial (RPE) cell line into the subretinal space of one such model, the Royal College of Surgeons (RCS) rat, and showed, using head tracking to moving stripes and pattern discrimination in conjunction with single-unit cortical physiology, that cortically mediated vision can be preserved with this treatment.Entities:
Mesh：
Year: 2002 PMID： 11753416 DOI： 10.1038/nn782
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884