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Literature DB >> 1175320

The effect of structural aberrations of the chromosomes on reproductive fitness in man. I. Methodology.

N E Morton, P A Jacobs, A Frackiewicz, P Law, C J Hilditch.

Abstract

Methods are presented to estimate relative fitness of carriers as a function of fertility, survival, are generation time in pedigrees under incomplete ascertainment. A large sample of diverse chromosomal aberrations reveals significant effects on all three parameters, giving a relative fitness of .769 +/- .039. There is no significant shift in segregation frequency. Implications of these results for population dynamics of structural rearrangements are discussed. The following paper applies these methods to specific classes of aberrations.

Entities: Species

Mesh：

Year: 1975 PMID： 1175320 DOI： 10.1111/j.1399-0004.1975.tb01489.x

Source DB: PubMed Journal: Clin Genet ISSN： 0009-9163 Impact factor: 4.438

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Cited

5 in total

1. FRAXA and FRAXE: evidence against segregation distortion and for an effect of intermediate alleles on learning disability.

Authors: J W Teague; N E Morton; N R Dennis; G Curtis; N McKechnie; J N Macpherson; A Murray; M C Pound; A J Sharrock; S A Youings; P A Jacobs
Journal: Proc Natl Acad Sci U S A Date: 1998-01-20 Impact factor: 11.205

2. The William Allan Memorial Award. Presented to Patricia A. Jacobs, D.Sc., at the annual meeting of the American Society of Human Genetics, Dallas, October 28-31, 1981.

Authors: J L Hamerton
Journal: Am J Hum Genet Date: 1982-09 Impact factor: 11.025

The effect of structural aberrations of the chromosomes on reproductive fitness in man. I. Methodology.

1. FRAXA and FRAXE: evidence against segregation distortion and for an effect of intermediate alleles on learning disability.

2. The William Allan Memorial Award. Presented to Patricia A. Jacobs, D.Sc., at the annual meeting of the American Society of Human Genetics, Dallas, October 28-31, 1981.

Review 3. Pericentric inversions. Problems and significance for clinical genetics.

4. Familial pericentric and paracentric inversions of chromosome 1.

5. Inheritance of a Ring Chromosome 21 in a Couple Undergoing In Vitro Fertilization (IVF): A Case Report.