M Gloor1, D Wolnicki. 1. Department of Dermatology, Klinikum der Stadt Karlsruhe, Germany. mgloor@onlinehome.de
Abstract
BACKGROUND: There are no published studies of the effect of methylrosaniline chloride (MRC) on inflammation when used at the concentration recommended in the New German Formulary. A tissue-damaging effect has been described in animal studies and at higher concentrations in humans. OBJECTIVE: To determine whether 0.5% MRC increases or reduces skin damage in irritative dermatitis. METHODS: The study was carried out on the sodium lauryl sulfate (SLS) skin irritation model in 18 healthy volunteers. The impact of intermittent treatment with 0.5% MRC or drug-free vehicle on three SLS exposure effects was determined: reduction of stratum corneum water content (corneometry), increase in subpapillary blood flow (laser Doppler method) and barrier damage (transepidermal water loss). RESULTS: MRC produced significant reductions in all three SLS exposure effects. CONCLUSIONS: Treatment of irritative dermatitis with 0.5% MRC is expected to produce a high clinical efficacy not only because of the compound's established antimicrobial activity, but also because of its anti-irritative effect. Copyright 2001 S. Karger AG, Basel
BACKGROUND: There are no published studies of the effect of methylrosaniline chloride (MRC) on inflammation when used at the concentration recommended in the New German Formulary. A tissue-damaging effect has been described in animal studies and at higher concentrations in humans. OBJECTIVE: To determine whether 0.5% MRC increases or reduces skin damage in irritative dermatitis. METHODS: The study was carried out on the sodium lauryl sulfate (SLS) skin irritation model in 18 healthy volunteers. The impact of intermittent treatment with 0.5% MRC or drug-free vehicle on three SLS exposure effects was determined: reduction of stratum corneum water content (corneometry), increase in subpapillary blood flow (laser Doppler method) and barrier damage (transepidermal water loss). RESULTS: MRC produced significant reductions in all three SLS exposure effects. CONCLUSIONS: Treatment of irritative dermatitis with 0.5% MRC is expected to produce a high clinical efficacy not only because of the compound's established antimicrobial activity, but also because of its anti-irritative effect. Copyright 2001 S. Karger AG, Basel