Crystallization and preliminary crystallographic studies of dimeric disintegrins from the venom of two Agkistrodon snakes.

Piscivostatin (PVS) and acostatin are members of the disintegrin family of platelet-aggregation inhibitors found in snake venoms and are dimeric disintegrins which play different roles to the monomeric disintegrins. The crystals of PVS belonged to the P2(1)2(1)2(1) space group, with unit-cell parameters a = 34.3, b = 54.4, c = 115.9 A, and diffracted to 2.0 A resolution. The crystals of acostatin belonged to the P2(1) space group, with unit-cell parameters a = 55.4, b = 69.3, c = 63.5 A, beta = 111.7 degrees, and diffracted to 2.8 A resolution.