Literature DB >> 11752663

Slit: a roadblock for chemotaxis.

A Z Fernandis1, R K Ganju.   

Abstract

The immune system and nervous system display striking similarities. Fernandis and Ganju discuss yet another example where a protein (Slit) originally identified for its role in modulating axon pathfinding is able to regulate immune cell migration. Slit isoforms expressed in the nervous system interact with members of the Robo receptor family to modify movement stimulated by the secreted attractants netrins and their receptors. In leukocytes, Slit 2 interacting with Robo receptors inhibits movement stimulated by the chemokine receptor (CXCR4). Fernandis and Ganju discuss the therapeutic potential of Slit as an antiviral agent and in the treatment of inflammatory diseases, autoimmune disorders, and cancer.

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Year:  2001        PMID： 11752663     DOI： 10.1126/stke.2001.91.pe1

Source DB:  PubMed          Journal:  Sci STKE        ISSN： 1525-8882


  8 in total

1.  Diversity, topographic differentiation, and positional memory in human fibroblasts.

Authors:  Howard Y Chang; Jen-Tsan Chi; Sandrine Dudoit; Chanda Bondre; Matt van de Rijn; David Botstein; Patrick O Brown
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-24       Impact factor: 11.205

2.  Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis.

Authors:  Cuiling Qi; Haimei Lan; Jie Ye; Weidong Li; Ping Wei; Yang Yang; Simei Guo; Tian Lan; Jiangchao Li; Qianqian Zhang; Xiaodong He; Lijing Wang
Journal:  Lab Invest       Date:  2014-05-19       Impact factor: 5.662

3.  Angiocrine factors modulate tumor proliferation and motility through EphA2 repression of Slit2 tumor suppressor function in endothelium.

Authors:  Dana M Brantley-Sieders; Charlene M Dunaway; Meghana Rao; Sarah Short; Yoonha Hwang; Yandong Gao; Deyu Li; Aixiang Jiang; Yu Shyr; Jane Y Wu; Jin Chen
Journal:  Cancer Res       Date:  2010-12-08       Impact factor: 12.701

4.  Slit-2/Robo-1 modulates the CXCL12/CXCR4-induced chemotaxis of T cells.

Authors:  Anil Prasad; Zahida Qamri; Jane Wu; Ramesh K Ganju
Journal:  J Leukoc Biol       Date:  2007-06-12       Impact factor: 4.962

5.  Slit2-Robo4 pathway modulates lipopolysaccharide-induced endothelial inflammation and its expression is dysregulated during endotoxemia.

Authors:  Helong Zhao; Appakkudal R Anand; Ramesh K Ganju
Journal:  J Immunol       Date:  2013-11-22       Impact factor: 5.422

6.  Genome-wide association study of antibody response to Newcastle disease virus in chicken.

Authors:  Chenglong Luo; Hao Qu; Jie Ma; Jie Wang; Chunyu Li; Chunfen Yang; Xiaoxiang Hu; Ning Li; Dingming Shu
Journal:  BMC Genet       Date:  2013-05-10       Impact factor: 2.797

7.  Cell signaling and transcription factor genes expressed during whole body regeneration in a colonial chordate.

Authors:  Yuval Rinkevich; Baruch Rinkevich; Ram Reshef
Journal:  BMC Dev Biol       Date:  2008-10-12       Impact factor: 1.978

8.  Transcriptome profiling of granulosa cells of bovine ovarian follicles during growth from small to large antral sizes.

Authors:  Nicholas Hatzirodos; Helen F Irving-Rodgers; Katja Hummitzsch; Margaret L Harland; Stephanie E Morris; Raymond J Rodgers
Journal:  BMC Genomics       Date:  2014-01-14       Impact factor: 3.969
  8 in total

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