Literature DB >> 11752658

TGF-beta flips the Myc switch.

A Orian1, R N Eisenman.   

Abstract

Although transforming growth factor-beta (TGF-beta) can affect cell cycle arrest, not much molecular detail is known about how TGF-beta-dependent arrest is mediated. Two recent papers shed some light on how this is accomplished. Orian and Eisenman discuss how Myc interacts with Miz-1 to block the expression of a cell cycle inhibitory protein, p15(INK4b), and how TGF-beta is able to unblock Myc-dependent repression of Miz-1.

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Year:  2001        PMID： 11752658     DOI： 10.1126/stke.2001.88.pe1

Source DB:  PubMed          Journal:  Sci STKE        ISSN： 1525-8882


  4 in total

Review 1.  Growth factor regulation of cell cycle progression in mammary epithelial cells.

Authors:  Malinda A Stull; Anne M Rowzee; Aimee V Loladze; Teresa L Wood
Journal:  J Mammary Gland Biol Neoplasia       Date:  2004-01       Impact factor: 2.673

2.  Measurement of relative copy number of CDKN2A/ARF and CDKN2B in bladder cancer by real-time quantitative PCR and multiplex ligation-dependent probe amplification.

Authors:  Joanne S Aveyard; Margaret A Knowles
Journal:  J Mol Diagn       Date:  2004-11       Impact factor: 5.568

3.  Resolvin E1-ChemR23 Axis Regulates the Hepatic Metabolic and Inflammatory Transcriptional Landscape in Obesity at the Whole Genome and Exon Level.

Authors:  Abrar E Al-Shaer; Anandita Pal; Saame Raza Shaikh
Journal:  Front Nutr       Date:  2021-12-24

4.  BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses.

Authors:  Huchun Li; Masayuki Sekine; Seyha Seng; Shalom Avraham; Hava Karsenty Avraham
Journal:  PLoS One       Date:  2009-09-21       Impact factor: 3.240
  4 in total

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