Literature DB >> 11752634

New responsibilities for the PI3K regulatory subunit p85 alpha.

K Okkenhaug1, B Vanhaesebroeck.   

Abstract

Class IA phosphoinositide-3 kinases (PI3Ks) are heterodimeric enzymes that regulate many signal transduction pathways. The p85 regulatory subunit recruits the p110 catalytic subunit to the membrane, where p110 phosphorylates inositol lipids. Recent studies present evidence for an additional role for p85alpha in the regulation of actin cytoskeleton. Okkenhaug and Vanhaesebroeck discuss these results and ask whether experiments describing p85alpha knockout mice need to be reinterpreted.

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Year:  2001        PMID： 11752634     DOI： 10.1126/stke.2001.65.pe1

Source DB:  PubMed          Journal:  Sci STKE        ISSN： 1525-8882


  23 in total

1.  Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis.

Authors:  Frédéric A Meunier; Shona L Osborne; Gerald R V Hammond; Frank T Cooke; Peter J Parker; Jan Domin; Giampietro Schiavo
Journal:  Mol Biol Cell       Date:  2005-07-29       Impact factor: 4.138

2.  A new approach to the molecular analysis of docking, priming, and regulated membrane fusion.

Authors:  Tatiana P Rogasevskaia; Jens R Coorssen
Journal:  J Chem Biol       Date:  2011-02-08

3.  The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation.

Authors:  Sang Won Park; Yingjiang Zhou; Justin Lee; Allen Lu; Cheng Sun; Jason Chung; Kohjiro Ueki; Umut Ozcan
Journal:  Nat Med       Date:  2010-03-28       Impact factor: 53.440

4.  p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis.

Authors:  Subha Krishnan; Raghuveer Singh Mali; Baskar Ramdas; Emily Sims; Peilin Ma; Joydeep Ghosh; Veerendra Munugalavadla; Philip Hanneman; Joal D Beane; Reuben Kapur
Journal:  Blood       Date:  2012-02-29       Impact factor: 22.113

5.  Src kinase-targeted anti-inflammatory activity of davallialactone from Inonotus xeranticus in lipopolysaccharide-activated RAW264.7 cells.

Authors:  Y G Lee; W M Lee; J Y Kim; J Y Lee; I-K Lee; B-S Yun; M H Rhee; J Y Cho
Journal:  Br J Pharmacol       Date:  2008-05-05       Impact factor: 8.739

6.  T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase.

Authors:  Anjali J de Souza; Jean S Oak; Ryan Jordanhazy; Rosemarie H DeKruyff; David A Fruman; Lawrence P Kane
Journal:  J Immunol       Date:  2008-05-15       Impact factor: 5.422

7.  Mechanisms of nuclear vitamin D receptor resistance in Harvey-ras-transfected cells.

Authors:  Laura M Taber; Lynn S Adams; Dorothy Teegarden
Journal:  J Nutr Biochem       Date:  2008-10-01       Impact factor: 6.048

8.  A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex.

Authors:  Fi-Tjen Mu; Robert K Andrews; Jane F Arthur; Adam D Munday; Susan L Cranmer; Shaun P Jackson; Frank C Stomski; Angel F Lopez; Michael C Berndt
Journal:  Blood       Date:  2008-02-25       Impact factor: 22.113

9.  LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation.

Authors:  Li Zhou; Yoshiharu Takayama; Philippe Boucher; Michelle D Tallquist; Joachim Herz
Journal:  PLoS One       Date:  2009-09-09       Impact factor: 3.240

10.  Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons.

Authors:  Hind Al-Qassab; Mark A Smith; Elaine E Irvine; Julie Guillermet-Guibert; Marc Claret; Agharul I Choudhury; Colin Selman; Kaisa Piipari; Melanie Clements; Steven Lingard; Keval Chandarana; Jimmy D Bell; Gregory S Barsh; Andrew J H Smith; Rachel L Batterham; Michael L J Ashford; Bart Vanhaesebroeck; Dominic J Withers
Journal:  Cell Metab       Date:  2009-11       Impact factor: 27.287
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