| Literature DB >> 11752454 |
L Susini1, B J Passer, N Amzallag-Elbaz, T Juven-Gershon, S Prieur, N Privat, M Tuynder, M C Gendron, A Israël, R Amson, M Oren, A Telerman.
Abstract
The Drosophila Seven in absentia (Sina) gene product originally was described as a protein that controls cell fate decisions during eye development. Its mammalian homolog, Siah-1, recently was found to be involved in p53-dependent and -independent pathways of apoptosis and G(1) arrest. We report that Siah-1 interacts directly with and promotes the degradation of the cell fate regulator Numb. Siah-1-mediated Numb degradation leads to redistribution of endogenous cell-surface Notch to the cytoplasm and nucleus and to augmented Notch-regulated transcriptional activity. These data imply that through its ability to target Numb for degradation, Siah-1 can act as a key regulator of Numb-related activities, including Notch signaling.Entities:
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Year: 2001 PMID： 11752454 PMCID： PMC64984 DOI： 10.1073/pnas.261571998
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205