UNLABELLED: Previous studies have shown that vertebral bone metastases (BM) not seen on planar bone scintigraphy (BS) might be present on (18)F-fluoride PET scans or at MRI. Therefore, we evaluated the effect of SPECT or (18)F-labeled NaF PET ((18)F PET) imaging on the management of patients with newly diagnosed lung cancer. METHODS: Fifty-three patients with small cell lung cancer or locally advanced non-small cell lung cancer were prospectively examined with planar BS, SPECT of the vertebral column, and (18)F PET. MRI and all available imaging methods, as well as the clinical course, were used as reference methods. BS with and without SPECT and (18)F PET were compared using a 5-point scale for receiver operating characteristic (ROC) curve analysis. RESULTS: Twelve patients had BM. BS produced 6 false-negatives, SPECT produced 1 false-negative, and (18)F PET produced no false-negatives. The area under the ROC curve was 0.779 for BS, 0.944 for SPECT, and 0.993 for (18)F PET. The areas under the ROC curve of (18)F PET and BS complemented by SPECT were not significantly different, and both tomographic methods were significantly more accurate than planar BS. As a result of SPECT or (18)F PET imaging, clinical management was changed in 5 patients (9%) or 6 patients (11%), respectively. CONCLUSION: As indicated by the area under the ROC curve analysis, (18)F PET is the most accurate whole-body imaging modality for screening for BM. Routinely performed SPECT imaging is practicable, is cost-effective, and improves the accuracy of BS.
UNLABELLED: Previous studies have shown that vertebral bone metastases (BM) not seen on planar bone scintigraphy (BS) might be present on (18)F-fluoride PET scans or at MRI. Therefore, we evaluated the effect of SPECT or (18)F-labeled NaF PET ((18)F PET) imaging on the management of patients with newly diagnosed lung cancer. METHODS: Fifty-three patients with small cell lung cancer or locally advanced non-small cell lung cancer were prospectively examined with planar BS, SPECT of the vertebral column, and (18)F PET. MRI and all available imaging methods, as well as the clinical course, were used as reference methods. BS with and without SPECT and (18)F PET were compared using a 5-point scale for receiver operating characteristic (ROC) curve analysis. RESULTS: Twelve patients had BM. BS produced 6 false-negatives, SPECT produced 1 false-negative, and (18)F PET produced no false-negatives. The area under the ROC curve was 0.779 for BS, 0.944 for SPECT, and 0.993 for (18)F PET. The areas under the ROC curve of (18)F PET and BS complemented by SPECT were not significantly different, and both tomographic methods were significantly more accurate than planar BS. As a result of SPECT or (18)F PET imaging, clinical management was changed in 5 patients (9%) or 6 patients (11%), respectively. CONCLUSION: As indicated by the area under the ROC curve analysis, (18)F PET is the most accurate whole-body imaging modality for screening for BM. Routinely performed SPECT imaging is practicable, is cost-effective, and improves the accuracy of BS.
Authors: L C McLoughlin; F O'Kelly; C O'Brien; M Sheikh; J Feeney; W Torreggiani; J A Thornhill Journal: Ir J Med Sci Date: 2014-11-14 Impact factor: 1.568
Authors: Karen A Kurdziel; Joanna H Shih; Andrea B Apolo; Liza Lindenberg; Esther Mena; Yolanda Y McKinney; Stephen S Adler; Baris Turkbey; William Dahut; James L Gulley; Ravi A Madan; Ola Landgren; Peter L Choyke Journal: J Nucl Med Date: 2012-06-22 Impact factor: 10.057
Authors: Frank I Lin; Jyotsna E Rao; Erik S Mittra; Kavitha Nallapareddy; Alka Chengapa; David W Dick; Sanjiv Sam Gambhir; Andrei Iagaru Journal: Eur J Nucl Med Mol Imaging Date: 2011-11-08 Impact factor: 9.236
Authors: Andrei Iagaru; Camila Mosci; David W Dick; Mike Sathekge; Paula Lapa; Joao M de Lima; Sanjiv Sam Gambhir Journal: Eur J Nucl Med Mol Imaging Date: 2013-09-21 Impact factor: 9.236
Authors: Constadina Arvanitis; Pavan K Bendapudi; Jeffrey R Tseng; Sanjiv Sam Gambhir; Dean W Felsher Journal: Cancer Biol Ther Date: 2008-12-07 Impact factor: 4.742