Y Yao1, T Kubota, K Sato, R Kitai. 1. Department of Neurosurgery, Fukui Medical University, Matsuoka, Fukui 910-1193, Japan. yaoyx@fmsrsa.fukui-med.ac.jp
Abstract
PURPOSE AND EXPERIMENTAL DESIGN: To clarify the significance of thymidine phosphorylase (TP)/platelet-derived endothelial cell growth factor/gliostatin in human glioma, we examined TP expression immunohistochemically in a series of 50 astrocytic tumors and correlated its expression with tumor angiogenesis and apoptosis, as well as prognosis. RESULTS: The majority of TP-positive cells were of macrophage origin, which was confirmed by immunostaining TP and CD68 on mirror sections. TP expression was significantly associated with glioma malignancy grading, intratumoral microvessel density, and VEGF expression but showed no relationship with apoptotic index or P53 expression. Regardless of glioma grading, patients with TP-positive tumors had a significantly shorter mean survival time than those with TP-negative tumors. CONCLUSIONS: These findings suggest that TP might play a crucial role in angiogenesis during glioma development, and immunodetection of TP is useful for clinical prediction. Further studies are necessary to better elucidate the role of TP in glioma, which may provide insights into adequate TP-targeted therapy.
PURPOSE AND EXPERIMENTAL DESIGN: To clarify the significance of thymidine phosphorylase (TP)/platelet-derived endothelial cell growth factor/gliostatin in humanglioma, we examined TP expression immunohistochemically in a series of 50 astrocytic tumors and correlated its expression with tumor angiogenesis and apoptosis, as well as prognosis. RESULTS: The majority of TP-positive cells were of macrophage origin, which was confirmed by immunostaining TP and CD68 on mirror sections. TP expression was significantly associated with glioma malignancy grading, intratumoral microvessel density, and VEGF expression but showed no relationship with apoptotic index or P53 expression. Regardless of glioma grading, patients with TP-positive tumors had a significantly shorter mean survival time than those with TP-negative tumors. CONCLUSIONS: These findings suggest that TP might play a crucial role in angiogenesis during glioma development, and immunodetection of TP is useful for clinical prediction. Further studies are necessary to better elucidate the role of TP in glioma, which may provide insights into adequate TP-targeted therapy.
Authors: Christine Lu-Emerson; Matija Snuderl; Nathaniel D Kirkpatrick; Jermaine Goveia; Christian Davidson; Yuhui Huang; Lars Riedemann; Jennie Taylor; Percy Ivy; Dan G Duda; Marek Ancukiewicz; Scott R Plotkin; Andrew S Chi; Elizabeth R Gerstner; April F Eichler; Jorg Dietrich; Anat O Stemmer-Rachamimov; Tracy T Batchelor; Rakesh K Jain Journal: Neuro Oncol Date: 2013-07-04 Impact factor: 12.300
Authors: Donald S Backos; Kristofer S Fritz; Debbie G McArthur; Jadwiga K Kepa; Andrew M Donson; Dennis R Petersen; Nicholas K Foreman; Christopher C Franklin; Philip Reigan Journal: Neurochem Res Date: 2013-06-07 Impact factor: 3.996