| Literature DB >> 1175130 |
H T Lynch, R J Thomas, P I Terasaki, A Ting, H A Guirgis, A R Kaplan, H Magee, J Lynch, C Kraft, E Chaperon.
Abstract
Actual HL-A typing has been performed on 115 members of cancer family N, a large kindred (over 1000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer-prone line (branches C and D) of the family, 20 of 21 members with cancer had one HL-A haplotype, HL-A2-HL-A12 (relative odds = 6.30), including some decreased family members who had haplotypes assigned. Eleven of 12 family members with cancer in branches C and D, actually typed, had HL-A2-HL-A12 (relative odds = 6.06). The single exception showing cancer and another haplotype in branch D is a child of a family member with haplotype HL-A2-HL-A12.Entities:
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Year: 1975 PMID： 1175130 DOI： 10.1002/1097-0142(197510)36:4<1315::aid-cncr2820360419>3.0.co;2-t
Source DB: PubMed Journal: Cancer ISSN： 0008-543X Impact factor: 6.860