Literature DB >> 11751149

Combination therapy with indolylquinoline derivative and sodium antimony gluconate cures established visceral leishmaniasis in hamsters.

Chiranjib Pal1, Mousumi Raha, Anirban Basu, Keshab Chandra Roy, Anasuya Gupta, Monidipa Ghosh, Niranjan Prasad Sahu, Sukdeb Banerjee, Nirup Bikash Mandal, Santu Bandyopadhyay.   

Abstract

2-(2"-Dichloroacetamidobenzyl)-3-(3'-indolylquinoline), designated indolylquinoline derivative A, reduced the splenic and the liver parasite burdens by >93.0% in Leishmania donovani-infected hamsters, whereas sodium antimony gluconate (SAG) reduced the burdens approximately 80.0%. Complete clearance of parasitemia from the livers and spleens was noticed when infected animals received indolylquinoline derivative A plus SAG, suggesting that indolylquinoline derivative A has potential as a new agent for sole or conjunctive therapy for leishmaniasis.

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Year:  2002        PMID： 11751149      PMCID： PMC126984          DOI： 10.1128/AAC.46.1.259-261.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes and amastigotes in vitro and are effective in treating murine visceral leishmaniasis.

Authors:  G Chakrabarti; A Basu; P P Manna; S B Mahato; N B Mandal; S Bandyopadhyay
Journal:  J Antimicrob Chemother       Date:  1999-03       Impact factor: 5.790

2.  Practical progress and new drugs for changing patterns of leishmaniasis.

Authors:  P L Olliaro; A D Bryceson
Journal:  Parasitol Today       Date:  1993-09

3.  Oral treatment of visceral leishmaniasis with miltefosine.

Authors:  S Sundar; L B Gupta; M K Makharia; M K Singh; A Voss; F Rosenkaimer; J Engel; H W Murray
Journal:  Ann Trop Med Parasitol       Date:  1999-09

4.  Cure of antimony-unresponsive Indian visceral leishmaniasis with amphotericin B lipid complex.

Authors:  S Sundar; H W Murray
Journal:  J Infect Dis       Date:  1996-03       Impact factor: 5.226

5.  Immunochemotherapy for Leishmania donovani infection in golden hamsters: combinatorial action of poly ICLC plus L-arginine and sodium stibogluconate (Stibanate).

Authors:  V Bhakuni; S Kulkarni; V Ali; U K Singh; H B Levy; R K Maheshwari
Journal:  J Interferon Cytokine Res       Date:  1999-10       Impact factor: 2.607

6.  Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani.

Authors:  R Lira; S Sundar; A Makharia; R Kenney; A Gam; E Saraiva; D Sacks
Journal:  J Infect Dis       Date:  1999-08       Impact factor: 5.226

7.  Miltefosine, an oral agent, for the treatment of Indian visceral leishmaniasis.

Authors:  T K Jha; S Sundar; C P Thakur; P Bachmann; J Karbwang; C Fischer; A Voss; J Berman
Journal:  N Engl J Med       Date:  1999-12-09       Impact factor: 91.245

8.  Short-course, cost-effective treatment with amphotericin B-fat emulsion cures visceral leishmaniasis.

Authors:  S Sundar; L B Gupta; V Rastogi; G Agrawal; H W Murray
Journal:  Trans R Soc Trop Med Hyg       Date:  2000 Mar-Apr       Impact factor: 2.184

9.  Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani.

Authors:  P C Melby; Y Z Yang; J Cheng; W Zhao
Journal:  Infect Immun       Date:  1998-01       Impact factor: 3.441

10.  Treatment of antimony-unresponsive Indian visceral leishmaniasis with ultra-short courses of amphotericin-B-lipid complex.

Authors:  S Sundar; A K Goyal; D K More; M K Singh; H W Murray
Journal:  Ann Trop Med Parasitol       Date:  1998-10
  10 in total
  3 in total

1.  Determination of drug-like properties of a novel antileishmanial compound: In vitro absorption, distribution, metabolism, and excretion studies.

Authors:  Susanta Kumar Mondal; Nirup B Mondal; Sukdeb Banerjee; Upal Kanti Mazumder
Journal:  Indian J Pharmacol       Date:  2009-08       Impact factor: 1.200

2.  Successful Therapy of Murine Visceral Leishmaniasis with Astrakurkurone, a Triterpene Isolated from the Mushroom Astraeus hygrometricus, Involves the Induction of Protective Cell-Mediated Immunity and TLR9.

Authors:  Suvadip Mallick; Aritri Dutta; Ankur Chaudhuri; Debasri Mukherjee; Somaditya Dey; Subhadra Halder; Joydip Ghosh; Debarati Mukherjee; Sirin Salma Sultana; Gunjan Biswas; Tapan Kumar Lai; Pradyumna Patra; Indranil Sarkar; Sibani Chakraborty; Bhaskar Saha; Krishnendu Acharya; Chiranjib Pal
Journal:  Antimicrob Agents Chemother       Date:  2016-04-22       Impact factor: 5.191

3.  Leishmanicidal Activity of Piper nigrum Bioactive Fractions is Interceded via Apoptosis In Vitro and Substantiated by Th1 Immunostimulatory Potential In Vivo.

Authors:  Garima Chouhan; Mohammad Islamuddin; Muzamil Y Want; Hani A Ozbak; Hassan A Hemeg; Dinkar Sahal; Farhat Afrin
Journal:  Front Microbiol       Date:  2015-12-08       Impact factor: 5.640
  3 in total

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