Literature DB >> 11751137

Postneurosurgical meningitis due to Proteus penneri with selection of a ceftriaxone-resistant isolate: analysis of chromosomal class A beta-lactamase HugA and its LysR-type regulatory protein HugR.

Nadia Liassine1, Stéphanie Madec, Béatrice Ninet, Catherine Metral, Martine Fouchereau-Peron, Roger Labia, Raymond Auckenthaler.   

Abstract

We report on a case of a postneurosurgical meningitis due to ceftriaxone-susceptible Proteus penneri, with selection of a ceftriaxone-resistant isolate following treatment with ceftriaxone. The isolates presented identical patterns by pulsed-field gel electrophoresis and produced a single beta-lactamase named HugA with an isoelectric point of 6.7. The ceftriaxone-resistant isolate hyperproduced the beta-lactamase (increase in the level of production, about 90-fold). The sequences of the hugA beta-lactamase gene and its regulator, hugR, were identical in both P. penneri strains and had 85.96% homology with those of Proteus vulgaris. The HugA beta-lactamase belongs to molecular class A, and the transcriptional regulator HugR belongs to the LysR family.

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Year:  2002        PMID： 11751137      PMCID： PMC126972          DOI： 10.1128/AAC.46.1.216-219.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

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  8 in total

1.  Identification of a chromosome-borne expanded-spectrum class a beta-lactamase from Erwinia persicina.

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Authors:  George A Jacoby
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Authors:  George A Jacoby
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5.  Genetic and biochemical characterization of the chromosomal class A beta-lactamases of Raoultella (formerly Klebsiella) planticola and Raoultella ornithinolytica.

Authors:  Estelle Walckenaer; Laurent Poirel; Véronique Leflon-Guibout; Patrice Nordmann; Marie-Hélène Nicolas-Chanoine
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6.  Origin and evolution of antibiotic resistance: the common mechanisms of emergence and spread in water bodies.

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7.  Clinical and microbiologic characteristics of cefotaxime-non-susceptible Enterobacteriaceae bacteremia: a case control study.

Authors:  Taro Noguchi; Yasufumi Matsumura; Masaki Yamamoto; Miki Nagao; Shunji Takakura; Satoshi Ichiyama
Journal:  BMC Infect Dis       Date:  2017-01-07       Impact factor: 3.090

8.  Regulation of Class A β-Lactamase CzoA by CzoR and IscR in Comamonas testosteroni S44.

Authors:  Weiping Zhuang; Hongliang Liu; Jingxin Li; Lu Chen; Gejiao Wang
Journal:  Front Microbiol       Date:  2017-12-22       Impact factor: 5.640
  8 in total

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