Literature DB >> 11751131

Efficacies of BMS 284756 against penicillin-sensitive, penicillin-resistant, and quinolone-resistant pneumococci in experimental meningitis.

Philippe Cottagnoud1, Fernando Acosta, Marianne Cottagnoud, Marc Pfister, Martin G Täuber.   

Abstract

BMS 284756 penetrated well into inflamed meninges (44% +/- 11%) and produced good bactericidal activity (-0.82 +/- 0.22 Delta log(10) CFU/ml. h) in the treatment of experimental meningitis in rabbits due to a penicillin-sensitive strain. BMS 284756 monotherapy had a greater potency than the standard regimen of ceftriaxone and vancomycin (-0.49 +/- 0.08 Delta log(10) CFU/ml. h) against a penicillin-resistant strain (MIC, 4 mg/liter). Even against a penicillin- and quinolone-resistant strain, BMS 284756 showed good bactericidal activity (-0.52 +/- 0.12 Delta log(10) CFU/ml. h). The antibacterial activity of BMS 284756 was confirmed by time-killing assays over 8 h in vitro.

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Year:  2002        PMID： 11751131      PMCID： PMC126974          DOI： 10.1128/AAC.46.1.184-187.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Grepafloxacin against penicillin-resistant pneumococci in the rabbit meningitis model.

Authors:  C M Gerber; L Tovar; M Cottagnoud; K A Neftel; M G Täuber; P Cottagnoud
Journal:  J Antimicrob Chemother       Date:  2000-08       Impact factor: 5.790

2.  A comparison of a Bayesian population method with two methods as implemented in commercially available software.

Authors:  J E Bennett; J C Wakefield
Journal:  J Pharmacokinet Biopharm       Date:  1996-08

Review 3.  A critical evaluation of vancomycin for treatment of bacterial meningitis.

Authors:  A Ahmed
Journal:  Pediatr Infect Dis J       Date:  1997-09       Impact factor: 2.129

4.  Making the most of sparse clinical data by using a predictive-model-based analysis, illustrated with a stavudine pharmacokinetic study.

Authors:  L Zhang; R Price; F Aweeka; S E Bellibas; L B Sheiner
Journal:  Eur J Pharm Sci       Date:  2001-02       Impact factor: 4.384

5.  Evaluation of cefepime alone and in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro.

Authors:  C M Gerber; M Cottagnoud; K Neftel; M G Täuber; P Cottagnoud
Journal:  J Antimicrob Chemother       Date:  2000-01       Impact factor: 5.790

6.  Isolation and characterization of vancomycin-tolerant Streptococcus pneumoniae from the cerebrospinal fluid of a patient who developed recrudescent meningitis.

Authors:  J A McCullers; B K English; R Novak
Journal:  J Infect Dis       Date:  2000-01       Impact factor: 5.226

7.  Evaluation of antimicrobial regimens for treatment of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis.

Authors:  I R Friedland; M Paris; S Ehrett; S Hickey; K Olsen; G H McCracken
Journal:  Antimicrob Agents Chemother       Date:  1993-08       Impact factor: 5.191

8.  Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives.

Authors:  R G Dacey; M A Sande
Journal:  Antimicrob Agents Chemother       Date:  1974-10       Impact factor: 5.191

9.  Microbioassay of antimicrobial agents.

Authors:  H J Simon; E J Yin
Journal:  Appl Microbiol       Date:  1970-04

10.  Rifampin for therapy of experimental pneumococcal meningitis in rabbits.

Authors:  R Nau; K Kaye; M Sachdeva; E R Sande; M G Täuber
Journal:  Antimicrob Agents Chemother       Date:  1994-05       Impact factor: 5.191
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  5 in total

1.  Daptomycin is highly efficacious against penicillin-resistant and penicillin- and quinolone-resistant pneumococci in experimental meningitis.

Authors:  Philippe Cottagnoud; Marc Pfister; Fernando Acosta; Marianne Cottagnoud; Lukas Flatz; Felix Kühn; Hans-Peter Müller; Armin Stucki
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

2.  Fluoroquinolones in the Treatment of Meningitis.

Authors:  Philippe Cottagnoud; Martin G. Täuber
Journal:  Curr Infect Dis Rep       Date:  2003-08       Impact factor: 3.725

3.  Modeling of transfer kinetics at the serum-cerebrospinal fluid barrier in rabbits with experimental meningitis: application to grepafloxacin.

Authors:  Marc Pfister; Liping Zhang; Margareta Hammarlund-Udenaes; Lewis B Sheiner; Cynthia M Gerber; Martin G Täuber; Philippe Cottagnoud
Journal:  Antimicrob Agents Chemother       Date:  2003-01       Impact factor: 5.191

4.  Activities of ertapenem, a new long-acting carbapenem, against penicillin-sensitive or -resistant pneumococci in experimental meningitis.

Authors:  P Cottagnoud; M Pfister; M Cottagnoud; F Acosta; M G Täuber
Journal:  Antimicrob Agents Chemother       Date:  2003-06       Impact factor: 5.191

5.  Efficacy of garenoxacin in treatment of experimental endocarditis due to Staphylococcus aureus or viridans group streptococci.

Authors:  José M Entenza; Jacques Vouillamoz; Michel P Glauser; Philippe Moreillon
Journal:  Antimicrob Agents Chemother       Date:  2004-01       Impact factor: 5.191
  5 in total

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