BACKGROUND: Although it has been hypothesized that glucocorticoid hypersecretion in depressed patients leads to neuronal atrophy in the hippocampus, magnetic resonance imaging (MRI) -based morphometry studies of the hippocampus to date have produced mixed results. METHODS: In our MRI study, hippocampal volumes were measured in 25 depressed patients (13 with melancholia and 12 without melancholia) and 15 control subjects. RESULTS: No significant differences in hippocampus volumes were found between any of the subject groups, although within subjects right hippocampal volumes were found to be significantly larger than left hippocampal volumes. Additionally, right and total (left + right) hippocampal volumes in control and depressed subjects were found to be positively correlated with trait anxiety as measured by the state/trait anxiety inventory. CONCLUSIONS: Because our subject group is younger than those in studies reporting hippocampal atrophy, we conclude that longitudinal studies will be necessary for investigation of the lifelong course of hippocampal volumetry.
BACKGROUND: Although it has been hypothesized that glucocorticoid hypersecretion in depressedpatients leads to neuronal atrophy in the hippocampus, magnetic resonance imaging (MRI) -based morphometry studies of the hippocampus to date have produced mixed results. METHODS: In our MRI study, hippocampal volumes were measured in 25 depressedpatients (13 with melancholia and 12 without melancholia) and 15 control subjects. RESULTS: No significant differences in hippocampus volumes were found between any of the subject groups, although within subjects right hippocampal volumes were found to be significantly larger than left hippocampal volumes. Additionally, right and total (left + right) hippocampal volumes in control and depressed subjects were found to be positively correlated with trait anxiety as measured by the state/trait anxiety inventory. CONCLUSIONS: Because our subject group is younger than those in studies reporting hippocampal atrophy, we conclude that longitudinal studies will be necessary for investigation of the lifelong course of hippocampal volumetry.
Authors: Megan A Miller; Regina L Leckie; Shannon D Donofry; Peter J Gianaros; Kirk I Erickson; Stephen B Manuck; Kathryn A Roecklein Journal: Hippocampus Date: 2015-01-20 Impact factor: 3.899
Authors: Marina Boccardi; Rossana Ganzola; Martina Bocchetta; Michela Pievani; Alberto Redolfi; George Bartzokis; Richard Camicioli; John G Csernansky; Mony J de Leon; Leyla deToledo-Morrell; Ronald J Killiany; Stéphane Lehéricy; Johannes Pantel; Jens C Pruessner; H Soininen; Craig Watson; Simon Duchesne; Clifford R Jack; Giovanni B Frisoni Journal: J Alzheimers Dis Date: 2011 Impact factor: 4.472
Authors: Turhan Canli; Maolin Qiu; Kazufumi Omura; Eliza Congdon; Brian W Haas; Zenab Amin; Martin J Herrmann; R Todd Constable; Klaus Peter Lesch Journal: Proc Natl Acad Sci U S A Date: 2006-10-10 Impact factor: 11.205
Authors: Sarah M Szymkowicz; Molly E McLaren; Andrew O'Shea; Adam J Woods; Stephen D Anton; Vonetta M Dotson Journal: Geriatr Gerontol Int Date: 2016-10-02 Impact factor: 2.730
Authors: P Cédric M P Koolschijn; Neeltje E M van Haren; Gerty J L M Lensvelt-Mulders; Hilleke E Hulshoff Pol; René S Kahn Journal: Hum Brain Mapp Date: 2009-11 Impact factor: 5.038