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Literature DB >> 11750807

Effects of mutating putative two-component systems on biofilm formation by Streptococcus mutans UA159.

Abstract

Streptococcus mutans has at least six pairs of open reading frames that are homologous to bacterial two-component regulatory systems. Putative response regulators from five out of six of these pairs were successfully mutated by insertion of a kanamycin resistance marker and the effects of inactivation of the genes on the ability of the cells to form biofilms in an in vitro model were assessed. Disruption of the response regulators of four systems had no effect on biofilm formation, whereas disruption of one response regulator caused a substantial decrease in biofilm formation as compared to the wild-type S. mutans.

Entities: Chemical Species

Mesh：

Year: 2001 PMID： 11750807 DOI： 10.1111/j.1574-6968.2001.tb10952.x

Source DB: PubMed Journal: FEMS Microbiol Lett ISSN： 0378-1097 Impact factor: 2.742

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Cited

36 in total

1. Biofilm mode of growth of Streptococcus intermedius favored by a competence-stimulating signaling peptide.

Authors: Fernanda C Petersen; Daniele Pecharki; Anne A Scheie
Journal: J Bacteriol Date: 2004-09 Impact factor: 3.490

2. The Streptococcus mutans serine/threonine kinase, PknB, regulates competence development, bacteriocin production, and cell wall metabolism.

Authors: Liliana Danusia Banu; Georg Conrads; Hubert Rehrauer; Haitham Hussain; Elaine Allan; Jan R van der Ploeg
Journal: Infect Immun Date: 2010-03-15 Impact factor: 3.441

3. A hypothetical protein of Streptococcus mutans is critical for biofilm formation.

Authors: Thomas A Brown; Sang-Joon Ahn; Roslyn N Frank; Yi-Ywan M Chen; José A Lemos; Robert A Burne
Journal: Infect Immun Date: 2005-05 Impact factor: 3.441

4. DNA binding-uptake system: a link between cell-to-cell communication and biofilm formation.

Authors: Fernanda C Petersen; Lin Tao; Anne A Scheie
Journal: J Bacteriol Date: 2005-07 Impact factor: 3.490

5. Development of an antivirulence drug against Streptococcus mutans: repression of biofilm formation, acid tolerance, and competence by a histidine kinase inhibitor, walkmycin C.

Authors: Yoko Eguchi; Norihiro Kubo; Hiroko Matsunaga; Masayuki Igarashi; Ryutaro Utsumi
Journal: Antimicrob Agents Chemother Date: 2011-01-31 Impact factor: 5.191

10. Involvement of Streptococcus mutans regulator RR11 in oxidative stress response during biofilm growth and in the development of genetic competence.

Authors: J A Perry; C M Lévesque; P Suntharaligam; R W Mair; M Bu; R T Cline; S N Peterson; D G Cvitkovitch
Journal: Lett Appl Microbiol Date: 2008-11 Impact factor: 2.858

Effects of mutating putative two-component systems on biofilm formation by Streptococcus mutans UA159.

1. Biofilm mode of growth of Streptococcus intermedius favored by a competence-stimulating signaling peptide.

2. The Streptococcus mutans serine/threonine kinase, PknB, regulates competence development, bacteriocin production, and cell wall metabolism.

3. A hypothetical protein of Streptococcus mutans is critical for biofilm formation.

4. DNA binding-uptake system: a link between cell-to-cell communication and biofilm formation.

5. Development of an antivirulence drug against Streptococcus mutans: repression of biofilm formation, acid tolerance, and competence by a histidine kinase inhibitor, walkmycin C.

Review 6. Streptococcus adherence and colonization.

7. The SloR/Dlg metalloregulator modulates Streptococcus mutans virulence gene expression.

8. Role of a nosX homolog in Streptococcus gordonii in aerobic growth and biofilm formation.

9. Influence of BrpA on critical virulence attributes of Streptococcus mutans.

10. Involvement of Streptococcus mutans regulator RR11 in oxidative stress response during biofilm growth and in the development of genetic competence.