Y M Zhang1, L Y Zhang, K Q Wang, J B Ge. 1. The Research Institute of Cardiovascular Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China.
Abstract
AIM: To observe the polymorphism of angiotensin-converting enzyme (ACE) gene in Northern Hans, Dahurs, and Ewenkis of China. METHODS: The polymerase chain reaction was used to type the insertion/deletion polymorphism at intron 16 of ACE gene among 90 Northern Hans, 84 Dahurs, and 64 Ewenkis individuals. The experiment displayed the distribution in three kinds of ACE genotype: ID (heterozygotes of insertion and deletion), DD (homozygotes of deletion), and II (homozytes of insertion). RESULTS: In Northern Hans the percentages of the distributing ACE I/D genotype were ID 27.8 %, DD 17.8 %, and II 54.4 %. The I/D genotype frequency of Dahurs individuals were ID 60.7 %, DD 26.2 %, and II 13.1 %. The Ewenkis genotype frequency were ID 70.3 %, DD 21.9 %, and II 7.8 %. CONCLUSION: The polymorphism of ACE gene of Northern Hans is different from that of Dahurs and Ewenkis in China.
AIM: To observe the polymorphism of angiotensin-converting enzyme (ACE) gene in Northern Hans, Dahurs, and Ewenkis of China. METHODS: The polymerase chain reaction was used to type the insertion/deletion polymorphism at intron 16 of ACE gene among 90 Northern Hans, 84 Dahurs, and 64 Ewenkis individuals. The experiment displayed the distribution in three kinds of ACE genotype: ID (heterozygotes of insertion and deletion), DD (homozygotes of deletion), and II (homozytes of insertion). RESULTS: In Northern Hans the percentages of the distributing ACE I/D genotype were ID 27.8 %, DD 17.8 %, and II 54.4 %. The I/D genotype frequency of Dahurs individuals were ID 60.7 %, DD 26.2 %, and II 13.1 %. The Ewenkis genotype frequency were ID 70.3 %, DD 21.9 %, and II 7.8 %. CONCLUSION: The polymorphism of ACE gene of Northern Hans is different from that of Dahurs and Ewenkis in China.
Authors: Masharip Atadzhanov; Mwila H Mwaba; Patrice N Mukomena; Shabir Lakhi; Peter Mwaba; Sruti Rayaprolu; James F Meschia; Owen A Ross Journal: BMC Res Notes Date: 2014-03-28