Literature DB >> 1174960

Behavioral changes in 2-month-old rats following prenatal exposure to antibodies against synaptic membranes.

S E Karpiak, M M Rapport.   

Abstract

Two-month-old male offspring of rats injected intravenously on day 19 of gestation with antiserum to synaptic membrane fraction showed marked behavioral deficits on a DRL (differential reinforcement at low rates) training paradigm. These behavioral deficits included perseveration, slow acquisition rates, and poor retention. Offspring of pregnant rats injected with antiserum to galactocerebroside or isotonic saline did not show these behavioral effects.

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Year:  1975        PMID: 1174960     DOI: 10.1016/0006-8993(75)90325-x

Source DB:  PubMed          Journal:  Brain Res        ISSN: 0006-8993            Impact factor:   3.252


  3 in total

1.  Dose-dependent effect of GM1 ganglioside during development on inhibitory avoidance behaviour in mice: influence of the period of administration.

Authors:  S Fagioli; C Rossi-Arnaud; C Castellano
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

Review 2.  Autoimmunity, Autoantibodies, and Autism Spectrum Disorder.

Authors:  Elizabeth Edmiston; Paul Ashwood; Judy Van de Water
Journal:  Biol Psychiatry       Date:  2016-09-01       Impact factor: 13.382

Review 3.  Maternal Antibody and ASD: Clinical Data and Animal Models.

Authors:  Adriana Gata-Garcia; Betty Diamond
Journal:  Front Immunol       Date:  2019-05-28       Impact factor: 7.561

  3 in total

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