Literature DB >> 117495

Effects of abrupt and gradual withdrawal from long-term haloperidol treatment on open field behavior of rats.

M M Bernardi, J P Neto.   

Abstract

The effects of abrupt and gradual withdrawal from long-term haloperidol treatment on rat open field behavior was studied. Abrupt withdrawal induced a significant increase in all parameters of activity observed except defecation, this increase being higher 72 h after the last haloperidol injection. Results were considered to be a consequence of supersensitivity of central dopaminergic receptors. These differences were almost unobservable in animals gradually withdrawn, thus suggesting that the phenomenon is reversible.

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Year:  1979        PMID： 117495     DOI： 10.1007/bf00492211

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  12 in total

1.  Drug-induced extrapyramidal reactions. Treatment with diphenhydramine hydrochloride and dihydroxyphenylalanine.

Authors:  P L MCGEER; J E BOULDING; W C GIBSON; R G FOULKES
Journal:  JAMA       Date:  1961-09-09       Impact factor: 56.272

2.  The effect of long-term penfluridol treatment on the sensitivity of the dopamine receptors in the nucleus accumbens and in the corpus striatum.

Authors:  D M Jackson; N E Andén; J Engel; S Liljequist
Journal:  Psychopharmacologia       Date:  1975-12-31

3.  The demonstration of a change in responsiveness of mice to physostigmine and atropine after withdrawal from long-term haloperidol pretreatment.

Authors:  R Dunstan; D M Jackson
Journal:  J Neural Transm       Date:  1977       Impact factor: 3.575

4.  Evaluation of psychotropic drugs with a modified open field test.

Authors:  J M Cunha; J Masur
Journal:  Pharmacology       Date:  1978       Impact factor: 2.547

5.  Behavioural supersensitivity to apomorphine following chronic treatment with drugs which interfere with the synaptic function of catecholamines.

Authors:  D Tarsy; R J Baldessarini
Journal:  Neuropharmacology       Date:  1974-11       Impact factor: 5.250

6.  Behavioral evidence for dopaminergic supersensitivity after chronic haloperidol.

Authors:  G Gianutsos; R B Drawbaugh; M D Hynes; H Lal
Journal:  Life Sci       Date:  1974-03-01       Impact factor: 5.037

Review 7.  Effect of methadone and dextromoramide on dopamine metabolism: comparison with haloperidol and amphetamine.

Authors:  G L Gessa; A Tagliamonte
Journal:  Neuropharmacology       Date:  1975-12       Impact factor: 5.250

8.  Inhibition and potentiation of apomorphine-induced hypermotility in rats by neuroleptics.

Authors:  J B Lassen
Journal:  Eur J Pharmacol       Date:  1976-04       Impact factor: 4.432

9.  Different behavioural patterns induced by apomorphine: evidence that the method of administration determines the behavioural response to the drug.

Authors:  T Ljungberg; U Ungerstedt
Journal:  Eur J Pharmacol       Date:  1977-11-01       Impact factor: 4.432

10.  Amphetamine-haloperidol interactions in rat striatum: failure to correlate behavioral effects with dopaminergic and cholinergic dynamics.

Authors:  R Kuczenski; D Schmidt; N Leith
Journal:  Brain Res       Date:  1977-04-22       Impact factor: 3.252
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  2 in total

1.  Relationship of orofacial movements to behavioural repertoire as assessed topographically over the course of 6-month haloperidol treatment followed by 4-month withdrawal.

Authors:  Ian E J De Souza; Niamh M Dawson; Jeremiah J Clifford; John L Waddington; Gloria E Meredith
Journal:  Psychopharmacology (Berl)       Date:  2003-06-27       Impact factor: 4.530

2.  Effects of single and long-term haloperidol administration on open field behavior of rats.

Authors:  M M Bernardi; H De Souza; J Palermo Neto
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530
  2 in total

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