OBJECTIVES: to compare heparin soaked fluoro-passivated gelatine sealed polyester and expanded polytetrafluoroethylene (ePTFE) patches in a sheep model of acute platelet accumulation following patch angioplasty. MATERIALS AND METHODS: heparin soaked patches were placed in the carotid arteries of 9 sheep and autologous (111)Indium labelled platelets were infused. The patches were explanted two hours after the injection of labelled platelets. Median specimen radioactivity was calculated as a ratio of radioactivity in explanted and in 4 ml of blood. Explanted patches were also investigated by scanning electron microscopy (SEM). RESULTS: platelet accumulation was significantly greater on ePTFE patches. For both materials platelet accumulation was greater at the distal end compared to the proximal (p<0.05). SEM demonstrated more platelets as well as thicker thrombus layer on ePTFE-patches. CONCLUSION: in sheep carotid arteries, a fluoropassivated gelatine sealed polyester patch appears to result in less platelet accumulation when compared to ePTFE. Copyright 2002 Harcourt Publishers Limited.
OBJECTIVES: to compare heparin soaked fluoro-passivated gelatine sealed polyester and expanded polytetrafluoroethylene (ePTFE) patches in a sheep model of acute platelet accumulation following patch angioplasty. MATERIALS AND METHODS:heparin soaked patches were placed in the carotid arteries of 9 sheep and autologous (111)Indium labelled platelets were infused. The patches were explanted two hours after the injection of labelled platelets. Median specimen radioactivity was calculated as a ratio of radioactivity in explanted and in 4 ml of blood. Explanted patches were also investigated by scanning electron microscopy (SEM). RESULTS: platelet accumulation was significantly greater on ePTFE patches. For both materials platelet accumulation was greater at the distal end compared to the proximal (p<0.05). SEM demonstrated more platelets as well as thicker thrombus layer on ePTFE-patches. CONCLUSION: in sheep carotid arteries, a fluoropassivated gelatine sealed polyester patch appears to result in less platelet accumulation when compared to ePTFE. Copyright 2002 Harcourt Publishers Limited.
Authors: Karina Schleimer; Houman Jalaie; Mamdouh Afify; Anna Woitok; Mohammad Esmaeil Barbati; Konrad Hoeft; Michael Jacobs; Rene H Tolba; Julia Steitz Journal: Acta Vet Scand Date: 2018-07-05 Impact factor: 1.695