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Literature DB >> 1174764

Reduction of antigen-induced contraction of sensitized human bronchus in vitro by indomethacin.

Abstract

1. Contraction of passively sensitized human bronchus induced by antigen challenge in vitro, was reduced by the prostaglandin F2alpha synthetase inhibitor, indomethacin. 2. Prostaglandin F2alpha was released during challenge and this release was inhibited by indomethacin. 3. There was a significant correlation between prostaglandin F2alpha release and antigen challenge-induced contraction, suggesting that this substance may contribute to the bronchoconstrictor response of sensitized human bronchus to antigen.

Entities: Chemical Species

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Year: 1975 PMID： 1174764 PMCID： PMC1666670 DOI： 10.1111/j.1476-5381.1975.tb07596.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

8 in total

1. Distribution of prostaglandins in human tissues.

Authors: S M Karim; M Sandler; E D Williams
Journal: Br J Pharmacol Chemother Date: 1967

2. Prostaglandin regulation of airway smooth muscle tone.

Authors: J Orehek; J S Douglas; A J Lewis; A Bouhuys
Journal: Nat New Biol Date: 1973-09-19

3. The isolation and determination of prostaglandins in lungs of sheep, guinea pig, monkey and man.

Authors: E Anggård
Journal: Biochem Pharmacol Date: 1965-11 Impact factor: 5.858

4. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

Authors: J R Vane
Journal: Nat New Biol Date: 1971-06-23

5. Increased plasma levels of 15-keto-13,14-dihydro-prostaglandin F2X after allergen-provoked asthma in man.

Authors: K Gréen; P Hedqvist; N Svanborg
Journal: Lancet Date: 1974-12-14 Impact factor: 79.321

6. Bronchial hyperreactivity to prostaglandin F 2 and histamine in patients with asthma.

Authors: A A Mathé; P Hedqvist; A Holmgren; N Svanborg
Journal: Br Med J Date: 1973-01-27

7. The release of spasmogenic substances from human chopped lung tissue and its inhibition.

Authors: P J Piper; J L Walker
Journal: Br J Pharmacol Date: 1973-02 Impact factor: 8.739

8. Radioimmunoassay of prostaglandin F-2-alpha in peripheral venous plasma from men and women.

Authors: J F Hennam; D A Johnson; J R Newton; W P Collins
Journal: Prostaglandins Date: 1974-03-25

8 in total

15 in total

1. Antigen-induced contraction of guinea-pig isolated trachea: studies with novel inhibitors and antagonists of arachidonic acid metabolites.

Authors: T R Jones; L Charette; D Denis
Journal: Br J Pharmacol Date: 1988-09 Impact factor: 8.739

Review 2. FPL 55712 -- an antagonist of slow reacting substance of anaphylaxis (SRS-A): a review.

Authors: N Chand
Journal: Agents Actions Date: 1979-06

Review 3. The Schultz-Dale reaction: a review.

Authors: N Chand; P Eyre
Journal: Agents Actions Date: 1978-04

9. Stimulation of the antigen-induced contraction of guinea-pig trachea and immunological release of histamine and SRS-A from sensitized guinea-pig lung by (2-isopropyl-3-indolyl)-3 pyridyl ketone (L8027) and indomethacin.

Authors: M Hitchcock
Journal: Br J Pharmacol Date: 1980 Impact factor: 8.739

10. Effect of histamine, acetylcholine and compound 48/80 on bronchoconstriction and release of eicosanoids in the dog.

Authors: I Zimmermann; B A Peskar; W T Ulmer; A A Bugalho de Almeida
Journal: Agents Actions Date: 1984-10