Literature DB >> 11747341

Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice.

A Balsari1, C Rumio, D Morelli, L Sfondrini, E Nardini, I Barajon, S Ménard.   

Abstract

One of the most severe side effects of anti-tumour chemotherapy is mucositis due to drug toxicity for rapidly dividing cells. We show here that anti-DXR monoclonal antibodies can prevent DXR-induced damage. Indeed, apoptosis, confined to the proliferative compartment of the basal mucosa, observed in the tongue of DXR-treated mice was completely inhibited by topical application of the anti-DXR antibodies.

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Year:  2001        PMID： 11747341      PMCID： PMC2364005          DOI： 10.1054/bjoc.2001.2188

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  16 in total

1.  A new monoclonal antibody recognizing anthracyclinic molecule.

Authors:  A Balsari; D Morelli; S Menard; E Tagliabue; M I Colnaghi; M Ghione
Journal:  Anticancer Res       Date:  1990 Jan-Feb       Impact factor: 2.480

2.  Stomatotoxic manifestations of cancer chemotherapy.

Authors:  S Dreizen
Journal:  J Prosthet Dent       Date:  1978-12       Impact factor: 3.426

3.  Protection against doxorubicin-induced alopecia in rats by liposome-entrapped monoclonal antibodies.

Authors:  A L Balsari; D Morelli; S Ménard; U Veronesi; M I Colnaghi
Journal:  FASEB J       Date:  1994-02       Impact factor: 5.191

4.  Prevention of chemotherapy-induced ulcerative mucositis by transforming growth factor beta 3.

Authors:  S T Sonis; L Lindquist; A Van Vugt; A A Stewart; K Stam; G Y Qu; K K Iwata; J D Haley
Journal:  Cancer Res       Date:  1994-03-01       Impact factor: 12.701

5.  Gut mucosa barrier preservation by orally administered IgA-IgG to patients undergoing bone marrow transplantation: a randomised pilot study.

Authors:  J E Johansson; T Ekman
Journal:  Bone Marrow Transplant       Date:  1999-07       Impact factor: 5.483

6.  Abrogation of adriamycin toxicity in vivo by cycloheximide.

Authors:  N S Thakkar; C S Potten
Journal:  Biochem Pharmacol       Date:  1992-04-15       Impact factor: 5.858

7.  Absorption of epidermal growth factor occurs through the gastrointestinal tract and oral cavity in adult rats.

Authors:  K R Purushotham; K Offenmüller; A T Bui; T Zelles; J Blazsek; G S Schultz; M G Humphreys-Beher
Journal:  Am J Physiol       Date:  1995-12

8.  An animal model for mucositis induced by cancer chemotherapy.

Authors:  S T Sonis; C Tracey; G Shklar; J Jenson; D Florine
Journal:  Oral Surg Oral Med Oral Pathol       Date:  1990-04

9.  Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

Authors:  Y Gavrieli; Y Sherman; S A Ben-Sasson
Journal:  J Cell Biol       Date:  1992-11       Impact factor: 10.539

10.  The nature of cytotoxic drug-induced cell death in murine intestinal crypts.

Authors:  T V Anilkumar; C E Sarraf; T Hunt; M R Alison
Journal:  Br J Cancer       Date:  1992-04       Impact factor: 7.640
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  2 in total

Review 1.  A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention.

Authors:  Christopher John Dunnill; Wafaa Al-Tameemi; Andrew Collett; Iain Stuart Haslam; Nikolaos Theodoros Georgopoulos
Journal:  Oncologist       Date:  2017-09-26

2.  Distribution of anticancer antibiotic daunomycin in the rat heart and kidney revealed by immunocytochemistry using monoclonal antibodies.

Authors:  Kunio Fujiwara; Masashi Shin; David M Hougaard; Lars-Inge Larsson
Journal:  Histochem Cell Biol       Date:  2006-07-19       Impact factor: 4.304
  2 in total

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