Marginal and dynamic regression models for longitudinal data.

Regression models for longitudinal data often employ random effects and serial correlation to account for residual variation between and within subjects. Most of these models are marginal models, separating the mean and covariance parameters. This paper discusses the use of dynamic models in which a lagged response serves as a predictor and compares these to marginal models. Regression parameters have a different interpretation in dynamic models as they describe changes in response levels, rather than the levels themselves. Lagged predictors are also useful with longitudinal data, explicitly quantifying the effect of previous levels of risk factors. These models are explored through analysis of data from the Childhood Respiratory Study, modelling lung function (FEV(1)) levels as a function of age, height, sex and smoking status in children measured over a five-year period. Copyright 2001 John Wiley & Sons, Ltd.