Literature DB >> 11746207

Chemopreventive efficacy of selenium against N-nitrosodiethylamine-induced hepatoma in albino rats.

C Thirunavukkarasu1, J P Singh, K Selvendiran, D Sakthisekaran.   

Abstract

The chemopreventive/chemotherapeutic effect of sodium selenite on tricarboxylic acid cycle key enzymes was investigated against hepatoma induced by environmental carcinogen N-nitrosodiethylamine. Decreased activities of TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH) in hepatoma and surrounding tissues of hepatoma-bearing rats were observed. Upon selenium supplementation the above biochemical changes were reverted in a dose- and duration-dependent manner. This study further confirms the chemopreventive/chemotherapeutic effect of sodium selenite which is found to be more effective in the initiation phase of carcinogenesis. Copyright 2001 John Wiley & Sons, Ltd.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11746207     DOI： 10.1002/cbf.924

Source DB:  PubMed          Journal:  Cell Biochem Funct        ISSN： 0263-6484            Impact factor:   3.685


  10 in total

1.  Oral supplementation of piperine leads to altered phase II enzymes and reduced DNA damage and DNA-protein cross links in Benzo(a)pyrene induced experimental lung carcinogenesis.

Authors:  Karuppaiyah Selvendiran; Syed Mumtaz Banu; Dhanapal Sakthisekaran
Journal:  Mol Cell Biochem       Date:  2005-01       Impact factor: 3.396

2.  Chemopreventive effect of piperine on mitochondrial TCA cycle and phase-I and glutathione-metabolizing enzymes in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice.

Authors:  K Selvendiran; C Thirunavukkarasu; J Prince Vijeya Singh; R Padmavathi; D Sakthisekaran
Journal:  Mol Cell Biochem       Date:  2005-03       Impact factor: 3.396

3.  Hypoglycaemic and biochemical properties of Cnestis ferruginea.

Authors:  Rahmat A Adisa; Mohammed I Choudhary; Elsie O Adewoye; Olufunso O Olorunsogo
Journal:  Afr J Tradit Complement Altern Med       Date:  2010-04-03

4.  Inhibition of cell proliferation and induction of apoptosis by genistein in experimental hepatocellular carcinoma.

Authors:  Dechen Chodon; S Mumtaz Banu; R Padmavathi; D Sakthisekaran
Journal:  Mol Cell Biochem       Date:  2006-09-28       Impact factor: 3.396

5.  Effect of an Established Nutritional Level of Selenium on Energy Metabolism and Gene Expression in the Liver of Rainbow Trout.

Authors:  Feifei Chen; Li Wang; Dianfu Zhang; Sai Li; Xuezhen Zhang
Journal:  Biol Trace Elem Res       Date:  2021-11-08       Impact factor: 3.738

6.  Inhibition of DNA alkylation damage with inorganic salts.

Authors:  Elizabeth E Hamilton; Jonathan J Wilker
Journal:  J Biol Inorg Chem       Date:  2004-09-16       Impact factor: 3.358

7.  Preventive effect of S-allyl cysteine sulphoxide (Alliin) on mitochondrial dysfunction in normal and isoproterenol induced cardiotoxicity in male Wistar rats: a histopathological study.

Authors:  T Sangeetha; S Darlin Quine
Journal:  Mol Cell Biochem       Date:  2009-03-05       Impact factor: 3.396

8.  Fisetin modulates mitochondrial enzymes and apoptotic signals in benzo(a)pyrene-induced lung cancer.

Authors:  Nagaiya Ravichandran; Gopal Suresh; Balasubramanian Ramesh; Ramar Manikandan; Young Whan Choi; Ganesan Vijaiyan Siva
Journal:  Mol Cell Biochem       Date:  2014-02-05       Impact factor: 3.396

9.  Chemopreventive effect of bacoside A on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats.

Authors:  Panneerselvam Janani; Kanakarajan Sivakumari; Arumugam Geetha; Baskaran Ravisankar; Chandrakesan Parthasarathy
Journal:  J Cancer Res Clin Oncol       Date:  2009-11-15       Impact factor: 4.553

10.  Inhibitory potential of methanolic extracts of Aristolochia tagala and Curcuma caesia on hepatocellular carcinoma induced by diethylnitrosamine in BALB/c mice.

Authors:  Khetbadei Lysinia Hynniewta Hadem; Rajeshwar Nath Sharan; Lakhan Kma
Journal:  J Carcinog       Date:  2014-05-30
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.