Literature DB >> 1174534

X-ray photoelectron spectroscopy of DNA-Pt complexes. Evidence of O6 (Gua)-N7 (Gua) chelation of DNA with cis- dichlorodiamine platinum(II).

M M Millard, J P Macquet, T Theophanides.   

Abstract

The binding energies of nitrogen, oxygen, phosphorus, chlorine and Pt in several DNA - Pt (II) complexes are reported and discussed. The nitrogen band of DNA is slightly shifted upon complexation with Pt. Oxygen binding energies in the complexes studied clearly show that cis-Pt(NH3)2Cl2 forms a specific chelate N7(Gua) - O6 (Gua) with DNA as opposed to trans-Pt(NH3)2Cl2 and the other Pt compounds which react only with the N7(Gua) site of DNA.

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Year:  1975        PMID： 1174534     DOI： 10.1016/0005-2787(75)90035-0

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  6 in total

1.  Electron microscopical demonstration of nucleic acids in virus-like particles in the skeletal muscle of a traffic accident victim.

Authors:  N Fukuhara
Journal:  Acta Neuropathol       Date:  1979-06-15       Impact factor: 17.088

2.  Cis-dichloro-diammine platinum (II) as stain for electron microscopic preparations.

Authors:  E Heinen
Journal:  Histochemistry       Date:  1977-03-04

Review 3.  A strategy for the development of two clinically active cisplatin analogs: CBDCA and CHIP.

Authors:  B J Foster; B J Harding; M K Wolpert-DeFilippes; L Y Rubinstein; K Clagett-Carr; B Leyland-Jones
Journal:  Cancer Chemother Pharmacol       Date:  1990       Impact factor: 3.333

Review 4.  [Cis-diamminedichloroplatinum(II). A new antineoplastic agent derived from the group of heavy metal complexes (author's transl)].

Authors:  R Osieka; C G Schmidt
Journal:  Klin Wochenschr       Date:  1979-12-03

5.  Some observations on the mechanisms of blocking of nuclear staining by cisplatin.

Authors:  A T Sumner
Journal:  Histochem J       Date:  1982-03

6.  Sensitive Marker of the Cisplatin-DNA Interaction: X-Ray Photoelectron Spectroscopy of CL.

Authors:  Fangxing Xiao; Xiaobin Yao; Qianhong Bao; Danzhen Li; Yi Zheng
Journal:  Bioinorg Chem Appl       Date:  2012-10-24       Impact factor: 7.778
  6 in total

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