| Literature DB >> 11745087 |
D Ribatti1, B Nico, A Vacca, L Roncali, P H Burri, V Djonov.
Abstract
The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane that is commonly used in vivo to study both angiogenesis and anti-angiogenesis. This review 1) summarizes the current knowledge about the structure of the CAM's capillary bed; 2) discusses the controversy about the existence of a single blood sinus or a capillary plexus underlying the chorionic epithelium; 3) describes a new model of the CAM vascular growth, namely the intussusceptive mode; 4) reports findings regarding the role played by endogenous fibroblast growth factor-2 in CAM vascularization; and 5) addresses the use and limitations of the CAM as a model for studying angiogenesis and anti-angiogenesis. Copyright 2001 Wiley-Liss, Inc.Entities:
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Year: 2001 PMID： 11745087 DOI： 10.1002/ar.10021
Source DB: PubMed Journal: Anat Rec ISSN： 0003-276X