| Literature DB >> 11745031 |
E K Song, H Cho, J S Kim, N Y Kim, N H An, J A Kim, S H Lee, Y C Kim.
Abstract
Assay-guided fractionation of the EtOAc soluble fraction of the rhizomes of Curcuma longa furnished three DPPH free radical scavenging diarylheptanoids, curcumin (1), demethoxycurcumin (2), and bisdemethoxycurcumin (3). Compounds 1-3 showed the DPPH radical scavenging effects with IC(50) values of 2.8, 39.2, 308.7 microM, respectively. L-Ascorbic acid and resveratrol as positive controls exhibited IC(50) values of 22.5 and 25.0 microM, respectively. Compounds 1-3 showed significant hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC(50) values of 1-3 are 86.9, 70.7, and 50.2 microM, respectively. Silybin (EC(50) = 69.0 microM) and silychristin (EC(50) = 82.7 microM) were used as positive controls.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11745031 DOI： 10.1055/s-2001-18860
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352