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Literature DB >> 1174445

Serum concentration measurements in man of the radiosensitizer Ro-07-0582: some preliminary results.

J L Foster, I R Flockhart, S Dische, A Gray, I Lenox-Smith, C E Smithen.

Abstract

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Year: 1975 PMID： 1174445 PMCID： PMC2009479 DOI： 10.1038/bjc.1975.115

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

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11 in total

1. Hypoxic cell radiosensitizers: comparative tests of some electron affinic compounds using epidermal cell survival in vivo.

Authors: J Denekamp; B D Michael; S R Harris
Journal: Radiat Res Date: 1974-10 Impact factor: 2.841

2. Electron affinic sensitization. V. Radiosensitization of hypoxic bacteria and mammalian cells in vitro by some nitroimidazoles and nitropyrazoles.

Authors: J C Asquith; M E Watts; K Patel; C E Smithen; G E Adams
Journal: Radiat Res Date: 1974-10 Impact factor: 2.841

3. Metronidazole ("Flagyl"). A radiosensitizer of hypoxic cells.

Authors: J C Asquith; J L Foster; R L Willson; R Ings; J A McFadzean
Journal: Br J Radiol Date: 1974-08 Impact factor: 3.039

4. Radiosensitization of anoxic cells by metronidazole.

Authors: J L Foster; R L Willson
Journal: Br J Radiol Date: 1973-03 Impact factor: 3.039

5. Tumor and normal tissue response to metronidazole and irradiation in mice.

Authors: H B Stone; H R Withers
Journal: Radiology Date: 1974-11 Impact factor: 11.105

6. Letter: "High-dose" metronidazole: a preliminary pharmacological study prior to its investigational use in clinical radiotherapy trials.

Authors: R C Urtasun; J Sturmwind; H Rabin; P R Band; J D Chapman
Journal: Br J Radiol Date: 1974-05 Impact factor: 3.039

7. Demonstration of radiosensitization of hypoxic cells in solid tumours by metronidazole.

Authors: A C Begg; P W Sheldon; J L Foster
Journal: Br J Radiol Date: 1974-07 Impact factor: 3.039

8. Absorptiometric, polarographic, and gas chromatographic assays for the determination of N-1-substituted nitroimidazoles in blood and urine.

Authors: J A DeSilva; N Munno; N Strojny
Journal: J Pharm Sci Date: 1970-02 Impact factor: 3.534

9. In vivo testing of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique.

Authors: A M Rauth; K Kaufman
Journal: Br J Radiol Date: 1975-03 Impact factor: 3.039

10. Human studies with "high dose" metronidazole: a non-toxic radiosensitizer of hypoxic cells.

Authors: G Deutsch; J L Foster; J A McFadzean; M Parnell
Journal: Br J Cancer Date: 1975-01 Impact factor: 7.640

11 in total

1. The neurotoxicity of misonidazole and its relationship to dose, half-life and concentration in the serum.

Authors: M E Saunders; S Dische; P Anderson; I R Flockhart
Journal: Br J Cancer Suppl Date: 1978-06

2. Some aspects of the metabolism of misonidazole.

Authors: I R Flockhart; S L Malcolm; T R Marten; C S Parkins; R J Ruane; D Troup
Journal: Br J Cancer Suppl Date: 1978-06

3. Further investigations of the effects of the hypoxic-cell radiosensitizer, Ro-07-0582, on local control of a mouse tumour.

Authors: P W Sheldon; S A Hill
Journal: Br J Cancer Date: 1977-08 Impact factor: 7.640

Serum concentration measurements in man of the radiosensitizer Ro-07-0582: some preliminary results.

1. Hypoxic cell radiosensitizers: comparative tests of some electron affinic compounds using epidermal cell survival in vivo.

2. Electron affinic sensitization. V. Radiosensitization of hypoxic bacteria and mammalian cells in vitro by some nitroimidazoles and nitropyrazoles.

3. Metronidazole ("Flagyl"). A radiosensitizer of hypoxic cells.

4. Radiosensitization of anoxic cells by metronidazole.

5. Tumor and normal tissue response to metronidazole and irradiation in mice.

6. Letter: "High-dose" metronidazole: a preliminary pharmacological study prior to its investigational use in clinical radiotherapy trials.

7. Demonstration of radiosensitization of hypoxic cells in solid tumours by metronidazole.

8. Absorptiometric, polarographic, and gas chromatographic assays for the determination of N-1-substituted nitroimidazoles in blood and urine.

9. In vivo testing of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique.

10. Human studies with "high dose" metronidazole: a non-toxic radiosensitizer of hypoxic cells.

1. The neurotoxicity of misonidazole and its relationship to dose, half-life and concentration in the serum.

2. Some aspects of the metabolism of misonidazole.

3. Further investigations of the effects of the hypoxic-cell radiosensitizer, Ro-07-0582, on local control of a mouse tumour.

4. Hypoxic cell radiosensitizers and local control by X-ray of a transplanted tumour in mice.

5. Radiosensitization by misonidazole (Ro-07-0582) of fractionated X-rays in a murine tumour.

6. The hypoxic cell sensitizer programme in the United States.

7. Clinical studies with misonidazole.

8. Effect of acute and chronic misonidazole administration on peripheral-nerve electrophysiology in mice.

9. Peripheral electrophysiological parameters in mice treated with misonidazole.

10. Pharmacokinetic considerations in testing hypoxic cell radiosensitizers in mouse tumours.