The biochemical substrate of nitric oxide signaling is present in primitive non-cognitive organisms.

Nitric oxide has been shown to have diverse actions in the mammalian nervous, immune and vascular systems. These include antimicrobial and antiviral activities as well as the modulation of cell adherence. In the nervous system, nitric oxide modulates neurotransmitter release, neurosecretion and behavioral activities such as feeding. In the present review, we discuss the finding that invertebrate organisms also contain nitric oxide and that they appear to use this multidimensional molecule in a similar manner as noted for mammals. Therefore, nitric oxide signaling appears to have emerged first in these primitive non-cognitive organisms. We conclude that basal nitric oxide functioning was established in these organisms and that this molecule was later employed in man, including its involvement in cognitive neural processes.