OBJECTIVES: Patients admitted to neonatal intensive care units (NICUs) are at high risk of nosocomial infection. We conducted a national multicenter assessment of nosocomial infections in NICUs to determine the prevalence of infections, describe associated risk factors, and help focus prevention efforts. STUDY DESIGN: We conducted a point prevalence survey of nosocomial infections in 29 Pediatric Prevention Network NICUs. Patients present on the survey date were included. Data were collected on underlying diagnoses, therapeutic interventions/treatments, infections, and outcomes. RESULTS: Of the 827 patients surveyed, 94 (11.4%) had 116 NICU-acquired infections: bloodstream (52.6%), lower respiratory tract (12.9%), ear-nose-throat (8.6%), or urinary tract infections (8.6%). Infants with infections were of significantly lower birth weight (median 1006 g [range 441 to 4460 g] vs 1589 g [range 326 to 5480 g]; P <.001) and had longer median durations of stay than those without infections (88 days [range 8 to 279 days] vs 32 days [range 1 to 483 days]; P <.001). Most common pathogens were coagulase-negative staphylococci and enterococci. Patients with central intravascular catheters (relative risk = 3.81, CI 2.32-6.25; P <.001) or receiving total parenteral nutrition (relative risk = 5.72, CI 3.45-9.49; P <.001) were at greater risk of bloodstream infection. CONCLUSIONS: This study documents the high prevalence of nosocomial infections in patients in NICUs and the urgent need for more effective prevention interventions.
OBJECTIVES:Patients admitted to neonatal intensive care units (NICUs) are at high risk of nosocomial infection. We conducted a national multicenter assessment of nosocomial infections in NICUs to determine the prevalence of infections, describe associated risk factors, and help focus prevention efforts. STUDY DESIGN: We conducted a point prevalence survey of nosocomial infections in 29 Pediatric Prevention Network NICUs. Patients present on the survey date were included. Data were collected on underlying diagnoses, therapeutic interventions/treatments, infections, and outcomes. RESULTS: Of the 827 patients surveyed, 94 (11.4%) had 116 NICU-acquired infections: bloodstream (52.6%), lower respiratory tract (12.9%), ear-nose-throat (8.6%), or urinary tract infections (8.6%). Infants with infections were of significantly lower birth weight (median 1006 g [range 441 to 4460 g] vs 1589 g [range 326 to 5480 g]; P <.001) and had longer median durations of stay than those without infections (88 days [range 8 to 279 days] vs 32 days [range 1 to 483 days]; P <.001). Most common pathogens were coagulase-negative staphylococci and enterococci. Patients with central intravascular catheters (relative risk = 3.81, CI 2.32-6.25; P <.001) or receiving total parenteral nutrition (relative risk = 5.72, CI 3.45-9.49; P <.001) were at greater risk of bloodstream infection. CONCLUSIONS: This study documents the high prevalence of nosocomial infections in patients in NICUs and the urgent need for more effective prevention interventions.
Authors: Vishal Hira; Marcel Sluijter; Wil H F Goessens; Alewijn Ott; Ronald de Groot; Peter W M Hermans; René F Kornelisse Journal: J Clin Microbiol Date: 2010-09-08 Impact factor: 5.948
Authors: Aaron M Milstone; Nicholas G Reich; Sonali Advani; Guoshu Yuan; Kristina Bryant; Susan E Coffin; W Charles Huskins; Robyn Livingston; Lisa Saiman; P Brian Smith; Xiaoyan Song Journal: Pediatrics Date: 2013-11-11 Impact factor: 7.124
Authors: Bruce Y Lee; Paul J Ufberg; Rachel R Bailey; Ann E Wiringa; Kenneth J Smith; Andrew J Nowalk; Conor Higgins; Angela R Wateska; Robert R Muder Journal: Vaccine Date: 2010-05-14 Impact factor: 3.641
Authors: Scott L Weiss; Julie C Fitzgerald; Edward Vincent Faustino; Marino S Festa; Ericka L Fink; Philippe Jouvet; Jenny L Bush; Niranjan Kissoon; John Marshall; Vinay M Nadkarni; Neal J Thomas Journal: Pediatr Crit Care Med Date: 2014-09 Impact factor: 3.624
Authors: Sylvia Maria Porto Pereira; Maria Helena Cabral de Almeida Cardoso; Ana Lucia Figuexeds; Haroldo Mattos; Ronaldo Rozembaum; Vanessa Isidoro Ferreira; Maria Antonieta Portinho; Ana Cristina Gonçalves; Elaine Sobral da Costa Journal: Int J Pediatr Date: 2010-02-21
Authors: Matthew J Bizzarro; Veronika Shabanova; Robert S Baltimore; Louise-Marie Dembry; Richard A Ehrenkranz; Patrick G Gallagher Journal: J Pediatr Date: 2015-05 Impact factor: 4.406