Literature DB >> 11742411

beta-Cell death during progression to diabetes.

D Mathis1, L Vence, C Benoist.   

Abstract

The hallmark of type 1 diabetes is specific destruction of pancreatic islet beta-cells. Apoptosis of beta-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. beta-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.

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Year:  2001        PMID： 11742411     DOI： 10.1038/414792a

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  287 in total

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Review 2.  In vivo immunogenetics: from MIC to RAET1 loci.

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5.  Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.

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Journal:  J Clin Invest       Date:  2002-09       Impact factor: 14.808

6.  GATA factors promote ER integrity and β-cell survival and contribute to type 1 diabetes risk.

Authors:  Daniel J Sartori; Christopher J Wilbur; Simon Y Long; Matthew M Rankin; Changhong Li; Jonathan P Bradfield; Hakon Hakonarson; Struan F A Grant; William T Pu; Jake A Kushner
Journal:  Mol Endocrinol       Date:  2013-01-01

7.  Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes.

Authors:  Ercument Dirice; Raymond W S Ng; Rachael Martinez; Jiang Hu; Florence F Wagner; Edward B Holson; Bridget K Wagner; Rohit N Kulkarni
Journal:  J Biol Chem       Date:  2017-08-31       Impact factor: 5.157

Review 8.  The mechanisms and applications of T cell vaccination for autoimmune diseases: a comprehensive review.

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10.  Differential responses of pancreatic β-cells to ROS and RNS.

Authors:  Gordon P Meares; Dominique Fontanilla; Katarzyna A Broniowska; Teresa Andreone; Jack R Lancaster; John A Corbett
Journal:  Am J Physiol Endocrinol Metab       Date:  2013-01-15       Impact factor: 4.310
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