Literature DB >> 11742253

Adrenomedullin regulates blood-brain barrier functions in vitro.

B Kis1, M A Deli, H Kobayashi, C S Abrahám, T Yanagita, H Kaiya, T Isse, R Nishi, S Gotoh, K Kangawa, A Wada, J Greenwood, M Niwa, H Yamashita, Y Ueta.   

Abstract

Adrenomedullin (AM) is an important vasodilator in cerebral circulation, and cerebral endothelial cells are a major source of AM. This in vitro study aimed to determine the AM-induced changes in blood-brain barrier (BBB) functions. AM administration increased, whereas AM antisense oligonucleotide treatment decreased transendothelial electrical resistance. AM incubation decreased BBB permeability for sodium fluorescein (mol. wt 376 Da) but not for Evan's blue albumin (mol. wt 67 kDa), and it also attenuated fluid-phase endocytosis. AM treatment resulted in functional activation of P-glycoprotein efflux pump in vitro. Our results indicate that AM as an autocrine mediator plays an important role in the regulation of BBB properties of the cerebral endothelial cells.

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Year:  2001        PMID： 11742253     DOI： 10.1097/00001756-200112210-00055

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  30 in total

Review 1.  In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use.

Authors:  Hans C Helms; N Joan Abbott; Malgorzata Burek; Romeo Cecchelli; Pierre-Olivier Couraud; Maria A Deli; Carola Förster; Hans J Galla; Ignacio A Romero; Eric V Shusta; Matthew J Stebbins; Elodie Vandenhaute; Babette Weksler; Birger Brodin
Journal:  J Cereb Blood Flow Metab       Date:  2016-02-11       Impact factor: 6.200

Review 2.  Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology.

Authors:  Máiria A Deli; Csongor S Abrahám; Yasufumi Kataoka; Masami Niwa
Journal:  Cell Mol Neurobiol       Date:  2005-02       Impact factor: 5.046

3.  Adrenomedullin improves the blood-brain barrier function through the expression of claudin-5.

Authors:  Masaru Honda; Shinsuke Nakagawa; Kentaro Hayashi; Naoki Kitagawa; Keisuke Tsutsumi; Izumi Nagata; Masami Niwa
Journal:  Cell Mol Neurobiol       Date:  2006-04-20       Impact factor: 5.046

4.  Differentiating embryonic neural progenitor cells induce blood-brain barrier properties.

Authors:  Christian Weidenfeller; Clive N Svendsen; Eric V Shusta
Journal:  J Neurochem       Date:  2007-01-24       Impact factor: 5.372

5.  Pericytes from brain microvessels strengthen the barrier integrity in primary cultures of rat brain endothelial cells.

Authors:  Shinsuke Nakagawa; Mária A Deli; Shinobu Nakao; Masaru Honda; Kentaro Hayashi; Ryota Nakaoke; Yasufumi Kataoka; Masami Niwa
Journal:  Cell Mol Neurobiol       Date:  2007-09-06       Impact factor: 5.046

6.  Adrenomedullin and elements of orthostatic competence after 41 h of voluntary submersion in water as measured in four healthy males.

Authors:  Ingrid Loder; Andreas Rössler; Gert Wurzinger; Roman Duncko; Daniela Jezova; Helmut Hinghofer-Szalkay
Journal:  Eur J Appl Physiol       Date:  2006-01-14       Impact factor: 3.078

7.  The blood-brain barrier permeability of geissoschizine methyl ether in Uncaria hook, a galenical constituent of the traditional Japanese medicine yokukansan.

Authors:  Sachiko Imamura; Masahiro Tabuchi; Hirotaka Kushida; Akinori Nishi; Hitomi Kanno; Takuji Yamaguchi; Kyoji Sekiguchi; Yasushi Ikarashi; Yoshio Kase
Journal:  Cell Mol Neurobiol       Date:  2011-03-26       Impact factor: 5.046

8.  Poly-ICLC preconditioning protects the blood-brain barrier against ischemic injury in vitro through type I interferon signaling.

Authors:  Raffaella Gesuete; Amy E B Packard; Keri B Vartanian; Valerie K Conrad; Susan L Stevens; Frances R Bahjat; Tao Yang; Mary P Stenzel-Poore
Journal:  J Neurochem       Date:  2012-11       Impact factor: 5.372

9.  Cilostazol strengthens barrier integrity in brain endothelial cells.

Authors:  Shoji Horai; Shinsuke Nakagawa; Kunihiko Tanaka; Yoichi Morofuji; Pierre-Oliver Couraud; Maria A Deli; Masaki Ozawa; Masami Niwa
Journal:  Cell Mol Neurobiol       Date:  2012-12-07       Impact factor: 5.046

10.  Endothelial nitric oxide synthase expression is progressively increased in primary cerebral microvascular endothelial cells during hyperbaric oxygen exposure.

Authors:  Xiongfei Xu; Zhongzhuang Wang; Quan Li; Xiang Xiao; Qinglin Lian; Weigang Xu; Xuejun Sun; Hengyi Tao; Runping Li
Journal:  Oxid Med Cell Longev       Date:  2009 Jan-Mar       Impact factor: 6.543
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