Literature DB >> 11742225

Are POMC neurons targets for sex steroids in the arcuate nucleus of the rat?

M Fodor1, H A Delemarre-van de Waal.   

Abstract

Testosterone alters the expression of proopiomelanocortin (POMC) mRNA in the neurons of the arcuate nucleus. While observations suggest that both estrogen and androgen receptors (AR) can mediate this action, only a negligible number of POMC neurons has previously been shown to contain estrogen receptor (ER)-alpha. To determine whether the putative action of testosterone is mediated via ER-beta or AR we double immuno- labeled hypothalamic sections from colchicine-pretreated male rats. Only few cells were immunostained for ER-beta and they were never found to co-localize POMC. In spite of the overlap in the anatomical distribution, only 3% of POMC cells appeared to contain AR. These results suggest that sex steroids have an indirect effect on most POMC neurons.

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Year:  2001        PMID： 11742225     DOI： 10.1097/00001756-200112210-00027

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  13 in total

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