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Literature DB >> 11741876

Biogenesis of T pili in Agrobacterium tumefaciens requires precise VirB2 propilin cleavage and cyclization.

Erh-Min Lai¹, Ralf Eisenbrandt, Markus Kalkum, Erich Lanka, Clarence I Kado.

Abstract

VirB2 propilin is processed by the removal of a 47-amino-acid signal peptide to generate a 74-amino-acid peptide product in both Escherichia coli and Agrobacterium tumefaciens. The cleaved VirB2 protein is further cyclized to form the T pilin in A. tumefaciens but not in E. coli. Mutations in the signal peptidase cleavage sequence of VirB2 propilin cause the formation of aberrant T pilin and also severely attenuate virulence. No T pilus was observed in these mutants. The potential role of the exact VirB2 propilin cleavage and cyclization in T pilus biogenesis and virulence is discussed.

Entities: Chemical Gene Species

Mesh：

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Year: 2002 PMID： 11741876 PMCID： PMC134783 DOI： 10.1128/JB.184.1.327-330.2002

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

13 in total

1. Conjugative pili of IncP plasmids, and the Ti plasmid T pilus are composed of cyclic subunits.

Authors: R Eisenbrandt; M Kalkum; E M Lai; R Lurz; C I Kado; E Lanka
Journal: J Biol Chem Date: 1999-08-06 Impact factor: 5.157

2. Subcellular localization of seven VirB proteins of Agrobacterium tumefaciens: implications for the formation of a T-DNA transport structure.

Authors: Y R Thorstenson; G A Kuldau; P C Zambryski
Journal: J Bacteriol Date: 1993-08 Impact factor: 3.490

3. VirB7 lipoprotein is exocellular and associates with the Agrobacterium tumefaciens T pilus.

Authors: V Sagulenko; E Sagulenko; S Jakubowski; E Spudich; P J Christie
Journal: J Bacteriol Date: 2001-06 Impact factor: 3.490

4. Genetic and environmental factors affecting T-pilin export and T-pilus biogenesis in relation to flagellation of Agrobacterium tumefaciens.

Authors: E M Lai; O Chesnokova; L M Banta; C I Kado
Journal: J Bacteriol Date: 2000-07 Impact factor: 3.490

Review 5. The T-pilus of Agrobacterium tumefaciens.

Authors: E M Lai; C I Kado
Journal: Trends Microbiol Date: 2000-08 Impact factor: 17.079

6. Maturation of IncP pilin precursors resembles the catalytic Dyad-like mechanism of leader peptidases.

Authors: R Eisenbrandt; M Kalkum; R Lurz; E Lanka
Journal: J Bacteriol Date: 2000-12 Impact factor: 3.490

7. Vir proteins stabilize VirB5 and mediate its association with the T pilus of Agrobacterium tumefaciens.

Authors: H Schmidt-Eisenlohr; N Domke; C Angerer; G Wanner; P C Zambryski; C Baron
Journal: J Bacteriol Date: 1999-12 Impact factor: 3.490

8. Membrane location of the Ti plasmid VirB proteins involved in the biosynthesis of a pilin-like conjugative structure on Agrobacterium tumefaciens.

Authors: K Shirasu; C I Kado
Journal: FEMS Microbiol Lett Date: 1993-08-01 Impact factor: 2.742

9. VirB2 is a processed pilin-like protein encoded by the Agrobacterium tumefaciens Ti plasmid.

Authors: A L Jones; E M Lai; K Shirasu; C I Kado
Journal: J Bacteriol Date: 1996-10 Impact factor: 3.490

10. Adsorption of tumorigenic Agrobacterium tumefaciens cells to susceptible potato tuber tissues.

Authors: S G Pueppke; U K Benny
Journal: Can J Microbiol Date: 1984-08 Impact factor: 2.419

23 in total

1. The Helicobacter pylori cag pathogenicity island protein CagN is a bacterial membrane-associated protein that is processed at its C terminus.

Authors: Kevin M Bourzac; Laura A Satkamp; Karen Guillemin
Journal: Infect Immun Date: 2006-05 Impact factor: 3.441

Biogenesis of T pili in Agrobacterium tumefaciens requires precise VirB2 propilin cleavage and cyclization.

1. Conjugative pili of IncP plasmids, and the Ti plasmid T pilus are composed of cyclic subunits.

2. Subcellular localization of seven VirB proteins of Agrobacterium tumefaciens: implications for the formation of a T-DNA transport structure.

3. VirB7 lipoprotein is exocellular and associates with the Agrobacterium tumefaciens T pilus.

4. Genetic and environmental factors affecting T-pilin export and T-pilus biogenesis in relation to flagellation of Agrobacterium tumefaciens.

Review 5. The T-pilus of Agrobacterium tumefaciens.

6. Maturation of IncP pilin precursors resembles the catalytic Dyad-like mechanism of leader peptidases.

7. Vir proteins stabilize VirB5 and mediate its association with the T pilus of Agrobacterium tumefaciens.

8. Membrane location of the Ti plasmid VirB proteins involved in the biosynthesis of a pilin-like conjugative structure on Agrobacterium tumefaciens.

9. VirB2 is a processed pilin-like protein encoded by the Agrobacterium tumefaciens Ti plasmid.

10. Adsorption of tumorigenic Agrobacterium tumefaciens cells to susceptible potato tuber tissues.

1. The Helicobacter pylori cag pathogenicity island protein CagN is a bacterial membrane-associated protein that is processed at its C terminus.

Review 2. Structures of naturally occurring circular proteins from bacteria.

Review 3. Unveiling molecular scaffolds of the type IV secretion system.

Review 4. Discovering the bacterial circular proteins: bacteriocins, cyanobactins, and pilins.

5. Processing and maturation of the pilin of the type IV secretion system encoded within the gonococcal genetic island.

Review 6. Biogenesis, architecture, and function of bacterial type IV secretion systems.

Review 7. Mechanism and structure of the bacterial type IV secretion systems.

Review 8. Phylogenomics reveals a diverse Rickettsiales type IV secretion system.

Review 9. Circular bacteriocins: biosynthesis and mode of action.

10. An anomalous type IV secretion system in Rickettsia is evolutionarily conserved.