Literature DB >> 11741609

Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli.

M Hintz1, A Reichenberg, B Altincicek, U Bahr, R M Gschwind, A K Kollas, E Beck, J Wiesner, M Eberl, H Jomaa.   

Abstract

The gcpE and lytB gene products control the terminal steps of isoprenoid biosynthesis via the 2-C-methyl-D-erythritol 4-phosphate pathway in Escherichia coli. In lytB-deficient mutants, a highly immunogenic compound accumulates significantly, compared to wild-type E. coli, but is apparently absent in gcpE-deficient mutants. Here, this compound was purified from E. coli DeltalytB mutants by preparative anion exchange chromatography, and identified by mass spectrometry, (1)H, (13)C and (31)P NMR spectroscopy, and NOESY analysis as (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP). HMB-PP is 10(4) times more potent in activating human Vgamma9/Vdelta2 T cells than isopentenyl pyrophosphate.

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Year:  2001        PMID： 11741609     DOI： 10.1016/s0014-5793(01)03191-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  135 in total

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2.  The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium.

Authors:  Jonathan A Eisen; Karen E Nelson; Ian T Paulsen; John F Heidelberg; Martin Wu; Robert J Dodson; Robert Deboy; Michelle L Gwinn; William C Nelson; Daniel H Haft; Erin K Hickey; Jeremy D Peterson; A Scott Durkin; James L Kolonay; Fan Yang; Ingeborg Holt; Lowell A Umayam; Tanya Mason; Michael Brenner; Terrance P Shea; Debbie Parksey; William C Nierman; Tamara V Feldblyum; Cheryl L Hansen; M Brook Craven; Diana Radune; Jessica Vamathevan; Hoda Khouri; Owen White; Tanja M Gruber; Karen A Ketchum; J Craig Venter; Hervé Tettelin; Donald A Bryant; Claire M Fraser
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-01       Impact factor: 11.205

3.  Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells.

Authors:  Matthias Eberl; Hassan Jomaa; Adrian C Hayday
Journal:  Immunology       Date:  2004-07       Impact factor: 7.397

4.  Auxin regulation of cytokinin biosynthesis in Arabidopsis thaliana: a factor of potential importance for auxin-cytokinin-regulated development.

Authors:  Anders Nordström; Petr Tarkowski; Danuse Tarkowska; Rikke Norbaek; Crister Astot; Karel Dolezal; Göran Sandberg
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-14       Impact factor: 11.205

Review 5.  Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity.

Authors:  Marc Bonneville; Rebecca L O'Brien; Willi K Born
Journal:  Nat Rev Immunol       Date:  2010-06-11       Impact factor: 53.106

Review 6.  CD8⁺ T Cell-Independent Immune-Mediated Mechanisms of Anti-Tumor Activity.

Authors:  G Elizabeth Pluhar; Christopher A Pennell; Michael R Olin
Journal:  Crit Rev Immunol       Date:  2015       Impact factor: 2.214

7.  A power law function describes the time- and dose-dependency of Vγ9Vδ2 T cell activation by phosphoantigens.

Authors:  Chia-Hung Christine Hsiao; Andrew J Wiemer
Journal:  Biochem Pharmacol       Date:  2018-11-02       Impact factor: 5.858

8.  Critical Roles for Coiled-Coil Dimers of Butyrophilin 3A1 in the Sensing of Prenyl Pyrophosphates by Human Vγ2Vδ2 T Cells.

Authors:  Hong Wang; Mohanad H Nada; Yoshimasa Tanaka; Shun Sakuraba; Craig T Morita
Journal:  J Immunol       Date:  2019-06-21       Impact factor: 5.422

9.  BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain.

Authors:  Mahboob Salim; Timothy J Knowles; Alfie T Baker; Martin S Davey; Mark Jeeves; Pooja Sridhar; John Wilkie; Carrie R Willcox; Hachemi Kadri; Taher E Taher; Pierre Vantourout; Adrian Hayday; Youcef Mehellou; Fiyaz Mohammed; Benjamin E Willcox
Journal:  ACS Chem Biol       Date:  2017-09-14       Impact factor: 5.100

10.  Expression and molecular analysis of the Arabidopsis DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway.

Authors:  Lorenzo Carretero-Paulet; Iván Ahumada; Nuria Cunillera; Manuel Rodríguez-Concepción; Albert Ferrer; Albert Boronat; Narciso Campos
Journal:  Plant Physiol       Date:  2002-08       Impact factor: 8.340
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